Identification of large genomic rearrangement of BRCA1/2 in high risk patients in Korea

BMC Medical Genetics

Table 1 Baseline characteristics of the study population

Characteristic	Total	Breast cancer	Ovarian cancer
Number	106	40^a (38%)	66 (62%)
Age, years
Mean (SD)	51 (12)	46	54
Age at diagnosis, years
Mean (SD)	48 (12)	44	51
High-risk features (BC)
Family history (1st-3rd degree)^d		19 (48%)^b
Early-onset (≤36 years)		11 (28%)^b
Bilateral		8 (20%)^b
BC + OC		7 (18%)^b
Multiple risks		9 (23%)^b
≥ 1 high-risk feature		35 (88%)^b
High-risk features (OC)
Family history (1st-3rd degree)^d			9 (14%)^c

BC breast cancer, OC ovarian cancer
^aSeven patients had both breast and ovarian cancer
^bThe percentage of patients with each high-risk feature among BC patients. Because of rounding, the total does not equal 100%
^cThe percentage of patients with high-risk feature among OC patients
^dFamily history of BC and/or OC in ≥1 close blood relatives (includes first-, second-, or third-degree relatives)

ISSN: 1471-2350