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Table 3 Number of polymorphisms detected in the coding regions of TLR1-TLR10. The AR population contains 288 individuals and the EUR population contains 379 individuals

From: Genetic variation of the Toll-like receptors in a Swedish allergic rhinitis case population

 

AR population

EUR population

Gene

Base-pairs

Total

≤ 1%a

AR-specificb

Newc

Missense

Nonsense

Synonymous

Damagingd

Total

≤ 1%a

EUR-specifice

Missense

Nonsense

Synonymous

Damagingd

TLR1

2358

14

8

4

1

9

1

4

3

19

13

9

14

0

5

6

TLR2

2352

10

5

4

1

6

1

3

3

10

5

4

4

0

6

2

TLR3

2712

8

6

4

4

6

0

2

4

12

10

8

7

0

5

4

TLR4

2517

11

9

5

2

5

0

6

2

13

11

7

9

0

4

2

TLR5

2574

15

9

4

1

10

1

4

1

17

11

6

11

2

4

2

TLR6

2388

11

6

5

3

7

0

4

1

16

11

10

12

0

4

3

TLR7

3147

8

5

4

1

5

0

3

1

5

2

1

3

0

2

1

TLR8

3123

9

3

2

2

2

0

7

0

9

2

2

1

0

8

0

TLR9

3096

15

13

9

5

6

0

9

3

15

13

9

6

1

8

2

TLR10

2433

18

4

2

1

13

0

5

3

26

12

10

16

1

9

4

Total

2358

119

68

43

21

69

3

47

21

142

90

66

83

4

55

26

  1. aPolymorphisms with minor allele frequencies ≤ 1%
  2. bPolymorphisms present in the AR population and not present in the EUR population
  3. cPolymorphisms not present in dbSNP
  4. dConcordant classification according to SIFT and PolyPhen-2
  5. ePolymorphisms present in the EUR population and not present in the AR population
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BMC Medical Genetics

ISSN: 1471-2350

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