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Table 2 Associations between microsatellite variants and measures of child behaviour, cognitive ability, personality/self-esteem and mental health (European sample only). The AP-2β minisatellite showed no significant association so was excluded from the table

From: Microsatellite polymorphisms associated with human behavioural and psychological phenotypes including a gene-environment interaction

 

AR-GGN homozygous major vs rest

AP-2β-CAAA homozygous major vs rest

TBR1

homozygous major vs rest

Measure

r

p

r

p

r

p

Childhood behaviour (7–9 years)

(N = 454–459)

(N = 582–589)

(N = 563–570)

Conduct problems

0.056

0.23

−0.055

0.18

0.141

0.0007**

Attention problems

0.049

0.29

−0.061

0.14

0.045

0.29

Anxiety/withdrawal

0.019

0.68

−0.039

0.34

0.103

0.015*

Cognitive abilitya

(N = 348–371)

(N = 451–482)

(N = 442–468)

WISC-R IQ (8–9 years)

−0.104

0.046*

0.085

0.062

−0.015

0.75

Scholastic ability (13 years)

−0.083

0.12

0.136

0.004*

−0.042

0.38

Personality/self-esteem

(N = 428–433)

(N = 554–557)

(N = 542–544)

EPI neuroticism (14 years)

0.039

0.41

−0.006

0.88

0.068

0.11

EPI extroversion (14 years)

−0.040

0.41

−0.072

0.08

0.061

0.16

TPI novelty seeking (16 years)

0.017

0.72

−0.045

0.29

0.034

0.43

Self-esteem (15 years)

−0.077

0.11

0.011

0.79

−0.051

0.23

Mental health (SCL-90, 18 years)

(N = 453)

(N = 588)

(N = 568)

Somatisation

0.060

0.15

−0.024

0.56

0.011

0.80

Anxiety

0.096

0.040*

0.020

0.63

0.022

0.60

Phobic anxiety

0.078

0.10

0.036

0.38

−0.022

0.61

Obsessive compulsive

0.037

0.44

−0.042

0.31

0.036

0.39

Depression

0.037

0.43

−0.009

0.83

0.037

0.38

Interpersonal sensitivity

0.060

0.21

0.012

0.78

0.054

0.20

Psychoticism

0.061

0.19

−0.110

0.008*

0.001

0.97

Paranoid ideation

0.081

0.086

−0.064

0.12

0.046

0.28

Hostility

−0.024

0.60

−0.028

0.49

0.087

0.039*

  1. aCognitive outcomes assessed only for cohort members resident in Christchurch urban region (approximately 80% of total cohort at each age)
  2. *Nominally significant (p < 0.05) but didn't withstand Bonferroni correction
  3. **Significant following Bonferroni correction