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Table 2 Number of variants by filter in three families using a dominant genetic model

From: Identification of novel candidate variants including COL6A6 polymorphisms in early-onset atopic dermatitis using whole-exome sequencing

Filter system

Dominant model

Filter step

Filter process

Family A

Family B

Family C

Raw

–

7523

3564

3227

Filter 1

EFFECT

2799

2489

2198

Filter 2

IMPACT

502

516

443

Filter 3

SIFT, PolyPhen2

278

258

231

Filter 4

phyloP

234

225

206

Filter 5

Phastcon

200

173

156

Filter 6

1000 genome

33

60

53

Filter 7

Korean

31

54

49

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BMC Medical Genetics

ISSN: 1471-2350

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