Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study

BMC Medical Genetics

Table 2 Results of genome-wide association analyses of renal urate excretion measures in Viva Hispanic children

SNP	Phenotype	Chr	Pos (GRCh38)	p (SNP)	β	SE	Effect size (%)	MAF	Gene symbol
rs2033711	UACl	19	58487983	7.9 × 10⁻⁰⁸	0.32	0.06	4.5	G (0.30)	ZNF446
rs10908521	UACl	1	56843858	3. 0 × 10⁻⁰⁷	−0.35	0.07	4.3	G (0.21)	INSRR
rs10423138	UACl	19	58416935	9. 4 × 10⁻⁰⁷	0.29	0.06	3.7	G (0.31)	ZNF584
rs9874872	UrUA/UrCr	3	31467743	1.8 × 10⁻⁰⁷	−0.38	0.07	4.7	A (0.18)
rs1353327	UrUA/UrCr	3	31461468	6. 8 × 10⁻⁰⁷	−0.49	0.10	4.1	A (0.10)
rs17079585	CrCl	13	23921903	2. 5 × 10⁻⁰⁷	−1.53	0.30	4.0	A (0.007)	ANKRD20A19P
rs4889855	FEUA	17	80539480	2. 7 × 10⁻⁰⁷	−0.29	0.06	4.9	G (0.43)
rs17079585	GLUA	13	23921903	5. 7 × 10⁻⁰⁷	−1.30	0.26	4.0	A (0.007)	ANKRD20A19P

SNP single nucleotide polymorphism, Chr Chromosome, Pos position in base pairs, p(SNP) p-value <1 × 10⁻⁷ shows evidence of significant association, p <1 × 10⁻⁶ shows evidence of suggestive association, β beta coefficient of the SNP, SE standard error of the beta coefficient; Effect Size: proportion of the residual phenotypic variance that is explained by the minor allele of the SNP; MAF minor allele frequency, UACl uric acid clearance, UrUA/UrCr urinary uric acid to urinary creatinine ratio, CrCl creatinine clearance, FEUA fractional excretion of uric acid, GLUA glomerular load of uric acid, ZNF446, zinc finger protein 446, INSRR Insulin receptor-related receptor, ZNF584 zinc finger protein 584, ANKRD20A19P ankyrin repeat domain 20 family, member A19, pseudogene

ISSN: 1471-2350