Skip to main content

Table 2 Results of genome-wide association analyses of renal urate excretion measures in Viva Hispanic children

From: Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study

SNP Phenotype Chr Pos (GRCh38) p (SNP) β SE Effect size (%) MAF Gene symbol
rs2033711 UACl 19 58487983 7.9 × 10−08 0.32 0.06 4.5 G (0.30) ZNF446
rs10908521 UACl 1 56843858 3. 0 × 10−07 −0.35 0.07 4.3 G (0.21) INSRR
rs10423138 UACl 19 58416935 9. 4 × 10−07 0.29 0.06 3.7 G (0.31) ZNF584
rs9874872 UrUA/UrCr 3 31467743 1.8 × 10−07 −0.38 0.07 4.7 A (0.18)  
rs1353327 UrUA/UrCr 3 31461468 6. 8 × 10−07 −0.49 0.10 4.1 A (0.10)  
rs17079585 CrCl 13 23921903 2. 5 × 10−07 −1.53 0.30 4.0 A (0.007) ANKRD20A19P
rs4889855 FEUA 17 80539480 2. 7 × 10−07 −0.29 0.06 4.9 G (0.43)  
rs17079585 GLUA 13 23921903 5. 7 × 10−07 −1.30 0.26 4.0 A (0.007) ANKRD20A19P
  1. SNP single nucleotide polymorphism, Chr Chromosome, Pos position in base pairs, p(SNP) p-value <1 × 10−7 shows evidence of significant association, p <1 × 10−6 shows evidence of suggestive association, β beta coefficient of the SNP, SE standard error of the beta coefficient; Effect Size: proportion of the residual phenotypic variance that is explained by the minor allele of the SNP; MAF minor allele frequency, UACl uric acid clearance, UrUA/UrCr urinary uric acid to urinary creatinine ratio, CrCl creatinine clearance, FEUA fractional excretion of uric acid, GLUA glomerular load of uric acid, ZNF446, zinc finger protein 446, INSRR Insulin receptor-related receptor, ZNF584 zinc finger protein 584, ANKRD20A19P ankyrin repeat domain 20 family, member A19, pseudogene