CpG Methylation across the adipogenic PPARγ gene and its relationship with birthweight and child BMI at 9 years

BMC Medical Genetics

Table 2 PPPPARγ methylation by sex

PPARγ Site	CpG Illumina ID	Classification^a	Methylation at birth (%)			Methylation at 9 years (%)
PPARγ Site	CpG Illumina ID	Classification^a	Male (N = 188)	Female (N = 185)	P value^b	Male (N = 113)	Female (N = 132)	P value^b
1	cg01412654	North Shore	65.8	67.8	0.002	71.5	73.1	0.018
2	cg25929976	North Shore	55.6	58.1	<0.001	62.5	65.4	<0.001
3	cg18063278	North Shore	59.1	62.1	<0.001	68.3	71.1	<0.001
4	cg26364899	Island	6.3	6.3	0.931	6.0	6.2	0.156
5	cg27095527	Island	4.3	4.5	0.289	4.0	4.6	0.380
6	cg06573644	Island	6.2	6.4	0.434	5.8	5.8	0.887
7	cg21946299	Island	9.0	8.9	0.445	9.1	9.0	0.724
8	cg23514324	Island	8.0	8.0	0.943	7.4	7.3	0.626
9	cg04748988	Island	2.3	2.3	0.636	2.0	2.0	0.570
10	cg15722404	Island	2.8	2.7	0.430	2.8	2.7	0.119
11	cg13518792	Island	1.0	1.0	0.297	1.0	1.0	0.564
12	cg09405169	Island	1.9	1.8	0.550	2.1	2.1	0.707
13	cg04632671	Island	1.0	1.1	0.115	1.4	1.2	0.054
14	cg07556134	Island	1.3	1.3	0.797	1.5	1.5	0.457
15	cg18887186	Island	9.8	9.9	0.372	12.5	12.5	0.709
16	cg21859053	South Shore	9.4	9.5	0.459	12.3	12.4	0.657
17	cg04908300	South Shore	15.4	15.9	0.107	24.8	25.7	0.030
18	cgl6827534	South Shelf	87.8	88.6	0.021	89.7	89.4	0.506
19	cg16197186	5′ UTR	91.1	91.3	0.398	92.0	91.9	0.996
20	cg18537222	Gene Body	51.5	52.1	0.612	57.1	58.4	0.345
21	cg07895576	Gene Body	90.1	90.3	0.244	90.7	90.6	0.707
22	cg07676920	Gene Body	85.1	85.0	0.930	85.9	85.4	0.513
23	cg10499651	Gene Body	79.0	78.8	0.632	77.1	78.2	0.084

ISSN: 1471-2350