Skip to main content

Table 3 Detection rates of WT1 mutations in children with SRNS in different ethnic groups

From: Screening of WT1 mutations in exon 8 and 9 in children with steroid resistant nephrotic syndrome from a single centre and establishment of a rapid screening assay using high-resolution melting analysis in a clinical setting

Ethnic background Total (Female/Male) Age of Onset (Median; Years) Number of cases with WT1 mutation (%) Prevalence of WT1 mutation in isolated SRNS (%)
Korean [35, 43] 424 (39/31) 4.7 25 (5.9%) 8 (1.9%)
Japanese [44] 13 (10/3) 0–1 month 0 0
Chinese [14] 52 (14/38) 3.5 1 (1.9%) 1 (1.9%)
Italian [17] 64 (32/32) 6.8 4 (6.2%) 2 (3%)
Spanish [45] 125 (NA) 1.3 5 (4%) NA
Greek [16] 27 (17/10) 8 4 (14.8%) 3 (11%)
Europe and Middle East [9] 761 2.0 61 (8%) 17 (2.23%)
Worldwide cohorta [33] 167 (80/87) 5.5 15 (9%) 11 (6.6%)
bWorldwide [7] 2016 (943/1067) 3.4 35 (1.7%) 32 (1.6%)
Indian (Current study) 100 (50/50) 2.6 0 (0%) 0 (0%)
  1. NA not available
  2. aCentral European, Turkish, African-American, Hispanic, or Asian
  3. bCentral Europe, Turkey, and India