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Table 3 Detection rates of WT1 mutations in children with SRNS in different ethnic groups

From: Screening of WT1 mutations in exon 8 and 9 in children with steroid resistant nephrotic syndrome from a single centre and establishment of a rapid screening assay using high-resolution melting analysis in a clinical setting

Ethnic background

Total (Female/Male)

Age of Onset (Median; Years)

Number of cases with WT1 mutation (%)

Prevalence of WT1 mutation in isolated SRNS (%)

Korean [35, 43]

424 (39/31)

4.7

25 (5.9%)

8 (1.9%)

Japanese [44]

13 (10/3)

0–1 month

0

0

Chinese [14]

52 (14/38)

3.5

1 (1.9%)

1 (1.9%)

Italian [17]

64 (32/32)

6.8

4 (6.2%)

2 (3%)

Spanish [45]

125 (NA)

1.3

5 (4%)

NA

Greek [16]

27 (17/10)

8

4 (14.8%)

3 (11%)

Europe and Middle East [9]

761

2.0

61 (8%)

17 (2.23%)

Worldwide cohorta [33]

167 (80/87)

5.5

15 (9%)

11 (6.6%)

bWorldwide [7]

2016 (943/1067)

3.4

35 (1.7%)

32 (1.6%)

Indian (Current study)

100 (50/50)

2.6

0 (0%)

0 (0%)

  1. NA not available
  2. aCentral European, Turkish, African-American, Hispanic, or Asian
  3. bCentral Europe, Turkey, and India