A targeted genome association study examining transient receptor potential ion channels, acetylcholine receptors, and adrenergic receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Table 1 Results of Fisher’s exact test for top 10 SNPs

Gene	SNP name	raw p-value	padj FDR	padj Bonferroni	Genotype	Controls allele frequency (%)	Cases allele frequency (%)	Odds ratios
ADRA1A	rs2322333	6.2e-05	0.059	0.059	AA	19	4	0.08
					AG	40	48	0.5
					GG	18	43	1
TRPM1	rs4779824	0.002	0.788	1	CC	34	4	0.02
					TC	39	51	0.26
					TT	4	20	1
TRPM6	rs11787707	0.004	0.788	1	AA	54	84	1
					AG	22	11	0.32
					GG	1	0	0
TRPM1	rs10467996	0.005	0.788	1	CC	4	17	5.72
					TC	34	49	1.94
					TT	39	29	1
TRPM3	rs10118380	0.01	0.788	1	CC	8	21	3.39
					TC	52	43	1.07
					TT	31	24	1
TRPM3	rs7022747	0.013	0.788	1	AG	8	1	NA
					GG	69	94	10.9
					AA	NA	NA	NA
CHRNB4	rs1316971	0.013	0.788	1	AA	10	0	0
					AG	38	32	0.65
					GG	46	60	0
ADRA1A	rs526302	0.013	0.788	1	GG	39	63	1
					TG	29	30	0.64
					TT	9	2	0.14
TRPM8	rs6719311	0.013	0.788	1	AA	0	0	NA
					AG	20	8	0.37
					GG	68	74	NA
ADRA1A	rs11782159	0.016	0.788	1	AA	29	21	1
					AC	39	50	1.77
					CC	9	24	3.68

Abbreviations: SNP single nucleotide polymorphism, padj adjusted p-value, FDR false detection rate, ADRA adrenergic receptor alpha, TRPM transient receptor potential melastatin ion channel, CHRN cholinergic receptor nicotinic beta

ISSN: 1471-2350