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Table 4 Results from a single marker generalised linear model for rs8192678 and BMI, T2D and gout

From: Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1A

 

Allele Freq (T)

HWE

Additive

P value

Dominant C (Gly)

P value

Dominant T (Ser)

P value

Heterozygous Advantage

P value

Linear regression between BMI and rs8192678 under the 4 genetic models. Beta (95% CI)

 NZ Caucasian

0.346

0.728

0.319 (−0.198, 0.835)

0.227

−0.555 (−1.618, 0.507)

0.305

0.350 (−0.358, 1.058)

0.332

0.102 (−0.601, 0.806)

0.775

 NZ Māori

0.806

0.721

0.629 (−0.848, 2.106)

0.403

−0.837 (−2.588, 0.913)

0.347

0.263 (−3.885, 4.412)

0.901

−0.831 (−2.625, 0.964)

0.363

 CI Māori

0.805

1.000

0.612 (−2.342, 3.566)

0.682

−0.627 (−3.940, 2.686)

0.709

1.319 (−8.733, 11.371)

0.795

−0.504 (−3.886, 2.879)

0.769

 Samoan

0.688

0.043

−0.610 (−2.605, 1.386)

0.548

0.705 (−1.757, 3.166)

0.573

−0.873 (−5.749, 4.002)

0.724

0.487 (−1.989, 2.964)

0.698

 Tongan

0.636

0.310

0.755 (−0.958, 2.468)

0.384

−0.895 (−3.382, 1.592)

0.477

1.336 (−2.118, 4.791)

0.445

−0.218 (−2.799, 2.363)

0.867

 Polynesian

0.747

0.925

0.345 (−0.611, 1.300)

0.479

−0.408 (−1.587, 0.770)

0.496

0.470 (−1.904, 2.843)

0.698

−0.301 (−1.496, 0.895)

0.621

Logistic regression between gout affection and rs8192678. OR (95% CI)

 NZ Caucasian

0.346

0.728

0.846 (0.683, 1.047)

0.125

1.290 (0.828, 1.996)

0.256

0.819 (0.612, 1.095)

0.180

0.916 (0.686, 1.221)

0.548

 NZ Māori

0.806

0.721

1.238 (0.737, 2.111)

0.425

0.896 (0.488, 1.635)

0.721

3.644 (0.697, 28.949)

0.159

1.071 (0.578, 1.977)

0.827

 CI Māori

0.805

1.000

0.785 (0.361, 1.654)

0.529

1.126 (0.488, 2.611)

0.780

-

-

0.936 (0.397, 2.202)

0.879

 Samoan

0.688

0.043

1.110 (0.638, 1.933)

0.711

1.097 (0.543, 2.220)

0.796

2.328 (0.658, 8.556)

0.189

1.437 (0.707, 2.975)

0.320

 Tongan

0.636

0.310

1.073 (0.562, 2.039)

0.829

1.248 (0.477, 3.310)

0.651

1.911 (0.543, 6.737)

0.308

1.991 (0.713, 5.971)

0.199

 Polynesian

0.747

0.925

1.149 (0.862, 1.533)

0.345

0.970 (0.678, 1.385)

0.865

2.024 (1.005, 4.126)

0.049

1.170 (0.814, 1.685)

0.396

Logistic regression between T2D and rs8192678. OR (95% CI)

 NZ Caucasian

0.346

0.728

1.046 (0.767, 1.419)

0.774

0.953 (0.523, 1.835)

0.880

1.065 (0.700, 1.630)

0.771

1.041 (0.686, 1.576)

0.850

 NZ Māori

0.806

0.721

0.768 (0.463, 1.294)

0.311

1.362 (0.737, 2.495)

0.319

0.706 (0.181, 3.535)

0.636

1.299 (0.692, 2.407)

0.409

 CI Māori

0.805

1.000

2.280 (0.901, 6.410)

0.096

0.348 (0.111, 0.977)

0.054

0.647 (0.037, 20.494)

0.777

0.314 (0.095, 0.910)

0.042

 Samoan

0.688

0.043

1.307 (0.630, 2.814)

0.480

0.788 (0.329, 1.886)

0.590

2.043 (0.316, 40.719)

0.527

0.904 (0.379, 2.142)

0.818

 Tongan

0.636

0.310

1.063 (0.477, 2.443)

0.882

0.961 (0.328, 2.888)

0.942

1.198 (0.233, 9.316)

0.841

1.030 (0.342, 3.045)

0.957

 Polynesian

0.747

0.925

1.738 (0.768, 4.219)

0.200

0.911 (0.610, 1.335)

0.646

1.104 (0.476, 2.901)

0.827

0.928 (0.617, 1.386)

0.716

  1. The marker was assessed under an additive model, dominance models and heterozygous advantage model. Models are adjusted for gout and diabetes affection, sex, age and non –Caucasian ancestry. Estimate (95% CI). NZ = New Zealand. CI = Cook Islands. Polynesian is a combination of NZ Māori, CI Māori, Samoan, and Tongan population groups. HWE = P-value for departure from Hardy Weinberg expectations using exact test, Logistic regression for CI Māori under the dominant T model could not be performed
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BMC Medical Genetics

ISSN: 1471-2350

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