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Table 4 Results from a single marker generalised linear model for rs8192678 and BMI, T2D and gout

From: Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1A

  Allele Freq (T) HWE Additive P value Dominant C (Gly) P value Dominant T (Ser) P value Heterozygous Advantage P value
Linear regression between BMI and rs8192678 under the 4 genetic models. Beta (95% CI)
 NZ Caucasian 0.346 0.728 0.319 (−0.198, 0.835) 0.227 −0.555 (−1.618, 0.507) 0.305 0.350 (−0.358, 1.058) 0.332 0.102 (−0.601, 0.806) 0.775
 NZ Māori 0.806 0.721 0.629 (−0.848, 2.106) 0.403 −0.837 (−2.588, 0.913) 0.347 0.263 (−3.885, 4.412) 0.901 −0.831 (−2.625, 0.964) 0.363
 CI Māori 0.805 1.000 0.612 (−2.342, 3.566) 0.682 −0.627 (−3.940, 2.686) 0.709 1.319 (−8.733, 11.371) 0.795 −0.504 (−3.886, 2.879) 0.769
 Samoan 0.688 0.043 −0.610 (−2.605, 1.386) 0.548 0.705 (−1.757, 3.166) 0.573 −0.873 (−5.749, 4.002) 0.724 0.487 (−1.989, 2.964) 0.698
 Tongan 0.636 0.310 0.755 (−0.958, 2.468) 0.384 −0.895 (−3.382, 1.592) 0.477 1.336 (−2.118, 4.791) 0.445 −0.218 (−2.799, 2.363) 0.867
 Polynesian 0.747 0.925 0.345 (−0.611, 1.300) 0.479 −0.408 (−1.587, 0.770) 0.496 0.470 (−1.904, 2.843) 0.698 −0.301 (−1.496, 0.895) 0.621
Logistic regression between gout affection and rs8192678. OR (95% CI)
 NZ Caucasian 0.346 0.728 0.846 (0.683, 1.047) 0.125 1.290 (0.828, 1.996) 0.256 0.819 (0.612, 1.095) 0.180 0.916 (0.686, 1.221) 0.548
 NZ Māori 0.806 0.721 1.238 (0.737, 2.111) 0.425 0.896 (0.488, 1.635) 0.721 3.644 (0.697, 28.949) 0.159 1.071 (0.578, 1.977) 0.827
 CI Māori 0.805 1.000 0.785 (0.361, 1.654) 0.529 1.126 (0.488, 2.611) 0.780 - - 0.936 (0.397, 2.202) 0.879
 Samoan 0.688 0.043 1.110 (0.638, 1.933) 0.711 1.097 (0.543, 2.220) 0.796 2.328 (0.658, 8.556) 0.189 1.437 (0.707, 2.975) 0.320
 Tongan 0.636 0.310 1.073 (0.562, 2.039) 0.829 1.248 (0.477, 3.310) 0.651 1.911 (0.543, 6.737) 0.308 1.991 (0.713, 5.971) 0.199
 Polynesian 0.747 0.925 1.149 (0.862, 1.533) 0.345 0.970 (0.678, 1.385) 0.865 2.024 (1.005, 4.126) 0.049 1.170 (0.814, 1.685) 0.396
Logistic regression between T2D and rs8192678. OR (95% CI)
 NZ Caucasian 0.346 0.728 1.046 (0.767, 1.419) 0.774 0.953 (0.523, 1.835) 0.880 1.065 (0.700, 1.630) 0.771 1.041 (0.686, 1.576) 0.850
 NZ Māori 0.806 0.721 0.768 (0.463, 1.294) 0.311 1.362 (0.737, 2.495) 0.319 0.706 (0.181, 3.535) 0.636 1.299 (0.692, 2.407) 0.409
 CI Māori 0.805 1.000 2.280 (0.901, 6.410) 0.096 0.348 (0.111, 0.977) 0.054 0.647 (0.037, 20.494) 0.777 0.314 (0.095, 0.910) 0.042
 Samoan 0.688 0.043 1.307 (0.630, 2.814) 0.480 0.788 (0.329, 1.886) 0.590 2.043 (0.316, 40.719) 0.527 0.904 (0.379, 2.142) 0.818
 Tongan 0.636 0.310 1.063 (0.477, 2.443) 0.882 0.961 (0.328, 2.888) 0.942 1.198 (0.233, 9.316) 0.841 1.030 (0.342, 3.045) 0.957
 Polynesian 0.747 0.925 1.738 (0.768, 4.219) 0.200 0.911 (0.610, 1.335) 0.646 1.104 (0.476, 2.901) 0.827 0.928 (0.617, 1.386) 0.716
  1. The marker was assessed under an additive model, dominance models and heterozygous advantage model. Models are adjusted for gout and diabetes affection, sex, age and non –Caucasian ancestry. Estimate (95% CI). NZ = New Zealand. CI = Cook Islands. Polynesian is a combination of NZ Māori, CI Māori, Samoan, and Tongan population groups. HWE = P-value for departure from Hardy Weinberg expectations using exact test, Logistic regression for CI Māori under the dominant T model could not be performed