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Table 1 Populations, genotyping platforms and analyses used to evaluate evidence of association and selection in PPARGC1A

From: Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1A

   Phenotype   
Population Genotyping Platform Gout (n) Control (n) Analysis
NZ Caucasian TaqMan SNP Assay 647 360 Single Marker GLM + FST on rs8192678
NZ Māori TaqMan SNP Assay 137 176 Single Marker GLM + FST on rs8192678
CI Māori TaqMan SNP Assay 71 64 Single Marker GLM + FST on rs8192678
Samoan TaqMan SNP Assay 144 76 Single Marker GLM + FST on rs8192678
Tongan TaqMan SNP Assay 73 41 Single Marker GLM + FST on rs8192678
Māori AXIOM SNP chip 35 36 FST, Fay and Wu’s H, Tajima’s D, iHS and XP-EHH
Samoan OMNIexpress chip 48 48 FST, Fay and Wu’s H, Tajima’s D, iHS and XP-EHH
   Unknown Phenotype   
1KGP CEU WGS 99   FST, Fay and Wu’s H, Tajima’s D, iHS and XP-EHH
1KGP CHB WGS 103   FST, Fay and Wu’s H, Tajima’s D, iHS and XP-EHH
1KGP CHS WGS 108   FST, Fay and Wu’s H, Tajima’s D, iHS and XP-EHH
1KGP GBR WGS 92   FST, Fay and Wu’s H, Tajima’s D, iHS and XP-EHH
1KGP YRI WGS 109   FST, Fay and Wu’s H, Tajima’s D, iHS and XP-EHH
  1. All individuals in the Māori AXIOM and Samoan OMNIexpress datasets were also genotyped by the TaqMan® assay, and included in their respective population groups. NZ = New Zealand. CI = Cook Islands. WGS = whole genome sequencing. 1KGP = 1000 genomes project (http://www.1000genomes.org/home). Populations used were Utah, USA residents with Northern and Western European ancestry (CEU, Han Chinese in Beijing, China (CHB), Southern Han Chinese (CHS), China, British in England and Scotland (GBR) and Yoruba in Ibadan, Nigeria YRI. For a complete description of the 1000 Genomes project samples see http://www.1000genomes.org/data#DataAvailable. No phenotypic data were available for these populations