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Fig. 2 | BMC Medical Genetics

Fig. 2

From: Three novel mutations of STK11 gene in Chinese patients with Peutz–Jeghers syndrome

Fig. 2

a The structure of STK11 gene. It contains a large kinase domain which spans from exon1 to exon 8. b Evolutionary conservation of amino acid residues altered by c.721G > C (p.Ala241Pro) and c.645_726del (p.Gly215GlyfsX45) across different species. c The mutant protein (p.Gly215GlyfsX45) was predicted to result in partial loss of the kinase domain and complete loss of the C-terminal domain of the a-helix by Swiss-Model online software compared to the wild type. The blue Gly215 indicates the mutant site

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