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CCM3/SERPINI1 bidirectional promoter variants in patients with cerebral cavernous malformations: a molecular and functional study

  • Concetta Scimone1, 2,
  • Placido Bramanti3,
  • Alessia Ruggeri1,
  • Luigi Donato1, 2,
  • Concetta Alafaci1,
  • Concetta Crisafulli1,
  • Massimo Mucciardi4,
  • Carmela Rinaldi1,
  • Antonina Sidoti1, 2Email author and
  • Rosalia D’Angelo1
BMC Medical GeneticsBMC series – open, inclusive and trusted201617:74

Received: 9 June 2015

Accepted: 29 September 2016

Published: 13 October 2016

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Open Peer Review reports

Pre-publication versions of this article are available by contacting

Original Submission
9 Jun 2015 Submitted Original manuscript
29 Sep 2015 Reviewed Reviewer Report - Robert Shenkar
29 Feb 2016 Reviewed Reviewer Report - David L. Corcoran
24 Jun 2016 Author responded Author comments - Concetta Scimone
Resubmission - Version 2
24 Jun 2016 Submitted Manuscript version 2
29 Sep 2016 Editorially accepted
13 Oct 2016 Article published 10.1186/s12881-016-0332-0

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting

You can find further information about the peer review system here.

Authors’ Affiliations

Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Division of Medical Biotechnologies and Preventive Medicine, University of Messina, Messina, Italy
Department of Cutting-Edge Medicine and Therapies, Biomolecular Strategies And Neuroscience, Section of Neuroscience-applied, Molecular Genetics and Predictive Medicine, I.E.ME.S.T, Palermo, Italy
IRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, Italy
Department of Economy, University of Messina, Messina, Italy