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Table 3 Genotype Frequencies for MTHFR, all cases (PD & PS)

From: Genetic causes of Parkinson’s disease in the Maltese: a study of selected mutations in LRRK2, MTHFR, QDPR and SPR

Polymorphism

Genotype frequencies

p-value

MTHFR c.677C > T

MTHFR c.1298A > C

No. of Cases (%)a

No. of Controls (%)a

Age-adjusted OR (95 % CI)b

 

CC

 

66 (43.7)

136 (43.7)

1

 

CT

 

68 (45.0)

134 (43.1)

1.0 (0.7–1.6)

0.8

TT

 

17 (11.3)

41 (13.2)

0.9 (0.5–1.6)

0.6

 

AA

60 (39.7)

132 (42.2)

1

 
 

AC

68 (45.0)

137 (43.8)

1.1 (0.7–1.7)

0.7

 

CC

23 (15.2)

44 (14.1)

1.2 (0.6–2.1)

0.6

CC

AA

16 (10.6)

24 (7.7)

1

 

CT

AC

41 (27.2)

67 (21.6)

0.9 (0.4–2.0)

0.8

TT

CC

-

-

-

 

CC

AC

27 (17.9)

69 (22.3)

0.6 (0.3–1.3)

0.2

CC

CC

23 (15.2)

43 (13.9)

0.8 (0.4–1.8)

0.6

CT

AA

27 (17.9)

66 (21.3)

0.6 (0.3–1.3)

0.2

CT

CC

-

-

-

 

TT

AA

17 (11.3)

41 (13.2)

0.6 (0.3–1.5)

0.3

TT

AC

-

-

-

 
  1. aDNA of 79 controls and 27 cases had been used up and were therefore not available and a few samples did not yield PCR products
  2. b p-values were all >0.05