Acyl-CoA synthetase long-chain 5 genotype is associated with body composition changes in response to lifestyle interventions in postmenopausal women with overweight and obesity: a genetic association study on cohorts Montréal-Ottawa New Emerging Team, and Complications Associated with Obesity

Table 6 Regression analysis studying lifestyle intervention effect in CT/TT vs CC women with overweight or obesity

Multiple regression model	Dependent variable	Number of subjects (n)	Parameter estimate	Standard error	Variable p-value	r² model	r² adjusted model	Model p-value
1	∆ BMI	123	−1.36	0.87	0.121	0.130	0.085	0.012
2	∆ Lean Mass	124	0.93	0.81	0.254	0.193	0.145	0.001
3	∆ Fat Mass	121	−3.82	1.66	0.023	0.213	0.164	<0.001
4	∆ % Lean Mass	126	2.33	0.94	0.014	0.248	0.203	<0.001
5	∆ % Fat Mass	121	−2.99	1.08	0.007	0.287	0.236	<0.001
6	∆ Visceral fat	124	−5.74	2.87	0.048	0.153	0.110	0.003
7	∆ Muscle attenuation	128	0.97	0.56	0.085	0.131	0.103	0.002

* Multiple linear regression analysis was conducted. Parameter estimate of independent variable = Xt was studied. Physiological factors (dependent variables) were studied while adjusting for confounding factors independent for each model (Table 1). Analysis was conducted on MONET and CAO studies combined

ISSN: 1471-2350