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Table 2 Association analysis of HNF1A with overall ischemic stroke

From: Association study of C-reactive protein associated gene HNF1A with ischemic stroke in Chinese population

SNP

Allele

Model

Unadjusted

Adjusted

OR

L95

U95

p-value

OR

L95

U95

p-value

rs1169302

T

Additive

0.97

0.84

1.12

0.67

0.93

0.78

1.10

0.37

Dominant

0.94

0.79

1.13

0.54

0.88

0.71

1.10

0.27

Recessive

1.02

0.74

1.40

0.91

0.98

0.67

1.44

0.93

Genotype TT

0.99

0.71

1.37

0.94

0.93

0.62

1.37

0.70

Genotype TG

0.94

0.77

1.13

0.49

0.88

0.70

1.10

0.26

rs1169306

C

Additive

1.03

0.91

1.17

0.65

1.00

0.85

1.17

0.99

Dominant

0.98

0.79

1.21

0.86

0.95

0.73

1.22

0.67

Recessive

1.10

0.89

1.37

0.36

1.14

0.88

1.47

0.32

Genotype CC

1.06

0.82

1.38

0.65

1.00

0.73

1.37

0.99

Genotype CT

0.94

0.75

1.18

0.62

0.83

0.63

1.08

0.16

rs1169307

T

Additive

0.95

0.79

1.15

0.61

0.95

0.75

1.20

0.69

Dominant

0.94

0.76

1.17

0.59

0.95

0.73

1.22

0.67

Recessive

0.98

0.47

2.04

0.96

0.98

0.39

2.48

0.97

Genotype TT

0.97

0.46

2.02

0.93

0.97

0.38

2.45

0.94

Genotype TC

0.94

0.76

1.17

0.59

0.94

0.73

1.23

0.67

rs2464196

G

Additive

1.04

0.91

1.18

0.58

1.01

0.86

1.18

0.89

Dominant

0.99

0.80

1.22

0.90

0.89

0.69

1.15

0.37

Recessive

1.12

0.90

1.39

0.30

1.16

0.90

1.50

0.26

Genotype GG

1.08

0.83

1.40

0.58

1.03

0.75

1.40

0.87

Genotype GA

0.94

0.76

1.18

0.62

0.83

0.64

1.09

0.18

rs2650000

A

Additive

0.90

0.79

1.02

0.09

0.91

0.78

1.07

0.26

Dominant

0.84

0.68

1.03

0.09

0.86

0.67

1.11

0.24

Recessive

0.89

0.72

1.10

0.28

0.91

0.71

1.18

0.49

Genotype AA

0.80

0.61

1.04

0.09

0.83

0.61

1.14

0.26

Genotype AC

0.85

0.68

1.07

0.16

0.87

0.67

1.14

0.32

rs7310409

A

Additive

0.97

0.85

1.11

0.69

1.01

0.86

1.18

0.94

Dominant

0.97

0.80

1.17

0.75

1.00

0.79

1.26

0.98

Recessive

0.96

0.75

1.23

0.74

1.03

0.76

1.37

0.87

Genotype AA

0.95

0.72

1.24

0.69

1.02

0.73

1.42

0.91

Genotype AG

0.98

0.80

1.20

0.82

0.99

0.77

1.27

0.93

rs7953249

G

Additive

0.90

0.79

1.03

0.12

0.91

0.77

1.06

0.22

Dominant

0.84

0.68

1.03

0.10

0.85

0.66

1.09

0.21

Recessive

0.90

0.72

1.13

0.36

0.91

0.70

1.19

0.48

Genotype GG

0.81

0.62

1.06

0.12

0.82

0.60

1.13

0.23

Genotype GA

0.85

0.69

1.06

0.16

0.86

0.66

1.12

0.27

  1. All SNPs were analyzed under allele, genotype, dominant and recessive models. Statistical analysis was performed using Chi-square test. P-value less than 0.05 were indicated in bold. Effect size was indicated in odds ratio (OR) with 95 % confidence interval (L95 and U95). After bonferroni correction, none of the associations highlighted in bold remained significant
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BMC Medical Genetics

ISSN: 1471-2350

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