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Table 3 Results from the lipid tolerance test in the siblingsa

From: Divergent phenotypes in siblings with identical novel mutations in the HNF-1α gene leading to maturity onset diabetes of the young type 3

  Normal value† Patient 1 (index) Patient 2
Glucose (mmol/l)
 0 h 5.33 12.3 13.7
 2 h 5.0 20.6 20.0
 4 h 4.9 15.8 14.2
Insulin (pmol/l)
 0 h 48.6 201.4 48.6
 2 h 340.3 305.6 208.4
 4 h 132.0 125.0 104.2
Total cholesterol (mmol/l)
 0 h 4.5 5.5 6.8
 2 h 4.5 5.6 6.4
 4 h 4.5 6.0 6.7
HDL cholesterol (mmol/l)
 0 h 1.3 1.5 0.7
 2 h 1.3 1.3 0.8
 4 h 1.3 1.3 0.8
Triglycerides (mmol/l)
 0 h <1.0 2.1 8.5
 2 h <1.6 4.8 11.6
 4 h <1.4 4.3 10.1
U-albumin (mg/l)
 0 h 35-50 30 67
 2 h na 6 46
 4 h na 40 19
Albumin/creatinine (g/molcrea)
 0 h <3.4 5.5 6.2
 2 h na 2.8 4.3
 4 h na 3.4 2.5
  1. HDL, high-density lipoprotein
  2. aClinical biochemical parameters of the siblings in a lipid tolerance test (10-h fasting period followed by breakfast of 1080 kcal [47 % fat, 40 % carbohydrates and 13 % proteins]) under current medication (patient 1: insulin; angiotensin-converting-enzyme inhibitors; patient 2 glinide; no lipid lowering therapy). †Mean values reported in healthy populations, na: not available