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Table 2 Results from the oral glucose tolerance test in the siblingsa

From: Divergent phenotypes in siblings with identical novel mutations in the HNF-1α gene leading to maturity onset diabetes of the young type 3

  Normal rangeb Patient 1 (index) Patient 2
Glucose (mmol/l)
 0 min <6.1 13.5 11.5
 60 min   21.0 21.0
 120 min <7.8 22.2 16.0
 180 min   15.8 11.7
Triglyceride (mmol/l) <1.71   
 0 min   3.2 6.1
 60 min   3.5 4.9
 120 min   3.5 4.4
 180 min   3.7 4.2
Total cholesterol (mmol/l) <5.2   
 0 min   6.6 6.5
 60 min   6.4 5.7
 120 min   6.4 5.7
 180 min   6.9 6.0
C-peptide (nmol/l) 0.27–1.72   
 0 min   0.4 0.7
 60 min   0.8 1.0
 120 min   0.6 1.2
 180 min   0.7 0.7
Insulin (pmol/l) 18.1–173.6   
 0 min   247.2 76.4
 60 min   209.7 84.0
 120 min   184.0 140.3
 180 min   139.3 36.8
  1. aClinical biochemical parameters of the siblings in an oral glucose tolerance test (75 mg oral glucose load) under current medication (patient 1: insulin; angiotensin-converting-enzyme inhibitors; patient 2 glinide; no lipid lowering therapy). bMean values reported in healthy populations, na: not available