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Table 1 Clinical biochemical variables in the siblings

From: Divergent phenotypes in siblings with identical novel mutations in the HNF-1α gene leading to maturity onset diabetes of the young type 3

Variable Normal range Patient 1 (index) Patient 2
Sex Female Male
Age at examination, years 43 39
Weight (kg) 69 93
Height (cm) 159 177
Waist circumference (cm) - 94 108
Body mass index (kg/m2) <25 27 30
Systolic/diastolic blood pressure (mmHg) 120/80 120/80 125/60
Fasting glucose (mmol/l) 4.1–6.1 12.7 12.8
Hemoglobin A1c (%) 4.8–5.9 7.4 8.9
Triglycerides (mmol/l) <1.7 2.2 6.9
Total cholesterol (mmol/l) <5.2 7.0 7.3
High-density lipoprotein cholesterol (mmol/l) >1.0 1.1 0.7
Low-density lipoprotein cholesterol (mmol/l) <4.2 4.8 3.4
Urea–albumin (mg/l) <20 22 73
Creatinine (mg/l) 5.3-8.9 3.5 6.2
Albumin/creatinine (g/molcrea) <2.3 4.9 8.2
Glutamic acid decarboxylase-antibodies (mlU/ml) <70 24.7 <5
Islet cell antibodies (JDF U) <5 1.3 1.3
Islet antigen 2 antibodies (mlU/ml) <70 <25 <1.3
C-peptide (nmol/l) 0.3–1.7 0.4 0.7
Insulin (pmol/l) 18.1–173.3 247.2* 76.4
Lipase (mmol*s/l) <100 46.7 145
  1. Data are shown as mean ± S.D. standard deviation. *: p-values < 0.05 (unpaired t-test with the assumption of normal distributed parameters) were accepted as significant