Table 1 Clinical biochemical variables in the siblings
Variable | Normal range | Patient 1 (index) | Patient 2 |
|---|---|---|---|
Sex | – | Female | Male |
Age at examination, years | – | 43 | 39 |
Weight (kg) | – | 69 | 93 |
Height (cm) | – | 159 | 177 |
Waist circumference (cm) | - | 94 | 108 |
Body mass index (kg/m2) | <25 | 27 | 30 |
Systolic/diastolic blood pressure (mmHg) | 120/80 | 120/80 | 125/60 |
Fasting glucose (mmol/l) | 4.1–6.1 | 12.7 | 12.8 |
Hemoglobin A1c (%) | 4.8–5.9 | 7.4 | 8.9 |
Triglycerides (mmol/l) | <1.7 | 2.2 | 6.9 |
Total cholesterol (mmol/l) | <5.2 | 7.0 | 7.3 |
High-density lipoprotein cholesterol (mmol/l) | >1.0 | 1.1 | 0.7 |
Low-density lipoprotein cholesterol (mmol/l) | <4.2 | 4.8 | 3.4 |
Urea–albumin (mg/l) | <20 | 22 | 73 |
Creatinine (mg/l) | 5.3-8.9 | 3.5 | 6.2 |
Albumin/creatinine (g/molcrea) | <2.3 | 4.9 | 8.2 |
Glutamic acid decarboxylase-antibodies (mlU/ml) | <70 | 24.7 | <5 |
Islet cell antibodies (JDF U) | <5 | 1.3 | 1.3 |
Islet antigen 2 antibodies (mlU/ml) | <70 | <25 | <1.3 |
C-peptide (nmol/l) | 0.3–1.7 | 0.4 | 0.7 |
Insulin (pmol/l) | 18.1–173.3 | 247.2* | 76.4 |
Lipase (mmol*s/l) | <100 | 46.7 | 145 |