BMC Medical Genetics

Table 1 Meta-analysis of the effect of KLKB1 and F12 genetic polymorphisms on generation of active renin in human plasma

From: Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system

KLKB1 (rs3733402)
Cohort	A1	A2	N	BETA	SE	P	MAF	HetISq	HetP	G/G Freq	G/A Freq	A/A Freq	HWE chi-square	HWE-p
TSP	G	A	381	−0.071	0.025	0.005	0.5			20.42%	49.17%	30.42%	0.399	0.712
MRS	G	A	799	−0.048	0.016	0.0037	0.47			20.40%	52.82%	26.78%	2.67	0.102
Meta-analysis	G	A	1180	−0.055	0.014	7.22E-05	0.48	0	0.507
F12 (rs1801020)
Cohort	A1	A2	N	BETA	SE	P	MAF	HetISq	HetP	A/A Freq	A/G Freq	G/G Freq	HWE chi-square	HWE-p
TSP	A	G	381	−0.061	0.031	0.0459	0.23			4.58%	33.75%	61.67%	0.514	0.426
MRS	A	G	798	−0.055	0.018	0.0026	0.24			6.14%	35.71%	58.15%	0.339	0.0561
Meta-analysis	A	G	1179	−0.057	0.016	0.0003	0.24	0	0.947

A1/A2: effect allele/non-effect allele, N: sample size, BETA: estimated beta coefficient, SE: standard error of beta, P: p-value for beta, MAF: minor allele frequency, HetP: p-value for Cochran's Q statistic, HetISq: I² heterogeneity index, TSP: twin & sibling participants, MRS: Marine resiliency study

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ISSN: 1471-2350

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