Fig. 7From: Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin systemHypothetical schematic representing activation of pro-renin by a proteolytic enzyme cascade of FXIIa → KAL, with consequences for regulation of BP. Pro-renin processing within the secretory granule of renal juxtaglomerular cells by sequential enzymatic events catalyzed by F12 and KALBack to article page