Table 1 PLCXD3 SNPs identified by GWAS and reported by Bishop et al. (†) and those subsequently resequenced by Bishop et al. (‡) are shown. P values are given for the discovery and replication studies. SNP positions refer to GRCh37 build
SNP ID | Position | Genomic-control corrected P-value Bishop et al. GWAS 85 vCJD cases vs. 1481 controls | Allelic Fisher Exact P-value Bishop et al. Resequencing 120 vCJD cases vs. publicly available controls | Allelic Fisher Exact P-value Bishop et al. Resequencing 109 sCJD cases vs. publicly available controls | Frequentist additive P- value MRC Prion Unit GWAS 129 vCJD cases vs. 5020 UK controls | Frequentist additive P-value MRC Prion Unit GWAS 2500 sCJD cases vs. 10548 controls |
|---|---|---|---|---|---|---|
rs3863150† | 5:41506860 | 1.53 x 10−08 | Not reported in study | Not reported in study | 0.000949 | 0.282 |
rs688551† | 5:41506080 | 1.53 x 10−08 | Not reported in study | Not reported in study | 0.000949 | 0.282 |
rs10075789† | 5:41505703 | 1.53 x 10−08 | Not reported in study | Not reported in study | 0.00105 | 0.282 |
rs676328† | 5:41505689 | 1.53 x 10−08 | Not reported in study | Not reported in study | 0.00115 | 0.257 |
rs545358‡ | 5:41382691 | Not reported in study | <2.2 x 10−16 | 2.01 x 10−5 | 0.668 | 0.788 |
rs319013‡ | 5:41382681 | Not reported in study | 1.25 x 10−06 | 4.69 x 10−8 | 0.331 | 0.139 |
rs76547469‡ | 5:41382647 | Not reported in study | 0.247 | 0.0702 | 0.545 | 0.624 |