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Table 4 Association of 32 GWA studies-derived SNP alleles with obesity in Chinese children

From: Association of common variants identified by recent genome-wide association studies with obesity in Chinese children: a case-control study

SNP

Nearest gene

Chr.

Allele

Obesity VS Normal-weight

Effect

other

OR

95 % CI

Two-sided

P-value

Speliotes et al. 2010 (in children and adults of European ancestry) [4]

rs1558902

FTO

16

A

T

1.31

1.01-1.69

0.039

rs2867125

TMEM18

2

C

T

1.06

0.79-1.42

0.703

rs571312

MC4R

18

A

C

1.16

0.94-1.42

0.166

rs10938397

GNPDA2

4

G

A

1.19

0.98-1.43

0.077

rs10767664

BDNF

11

A

T

1.10

0.93-1.30

0.273

rs2815752

NEGR1

1

A

G

1.07

0.79-1.46

0.645

rs7359397

SH2B1

16

T

C

1.06

0.85-1.34

0.597

rs9816226

ETV5

3

T

A

0.90

0.56-1.45

0.669

rs3817334

MTCH2

11

T

C

1.05

0.88-1.25

0.626

rs29942

KCTD15

19

C

T

1.01

0.83-1.23

0.949

rs543874

SEC16B

1

G

A

1.41

1.15-1.73

0.001

rs987237

TFAP2B

6

G

A

1.27

1.02-1.59

0.032

rs7138803

FAIM2

12

A

G

1.06

0.87-1.30

0.542

rs713586

RBJ

2

C

T

1.19

1.00-1.42

0.048

rs2241423

MAP2K5

15

G

A

1.34

1.12-1.59

0.001

rs2287019

QPCTL

19

C

T

0.89

0.72-1.10

0.283

rs1514175

TNNI3K

1

A

G

1.11

0.90-1.36

0.332

rs2112347

FLJ35779

5

T

G

1.02

0.85-1.21

0.865

rs16912921

LRRN6C

9

A

C

0.95

0.79-1.15

0.628

rs3810291

TMEM160

19

A

G

0.93

0.77-1.12

0.456

rs1555543

PTBP2

1

C

A

0.84

0.65-1.08

0.174

rs9579083

MTIF3

13

C

G

1.08

0.85-1.37

0.519

rs4929949

RPL27A

11

C

T

0.90

0.75-1.07

0.215

rs206936

NUDT3

6

G

A

0.99

0.83-1.18

0.919

Scherag et al. 2010 (in children and adults of European ancestry)[6]

rs12145833

SDCCAG8

1

T

G

0.96

0.71-1.31

0.799

rs13278851

TNKS/MSRA

8

A

G

0.90

0.71-1.14

0.375

Bradfield et al. 2012 (in children of European ancestry) [5]

rs9568856

OLFM4

13

A

G

1.08

0.89-1.30

0.438

rs9299

HOXB5

17

A

G

1.07

0.90-1.27

0.449

Okada et al. 2012 (in East Asians) [8]

rs2206734

CDKAL1

6

G

A

1.21

1.01-1.44

0.035

rs11142387

KLF9

9

C

A

0.90

0.75-1.08

0.268

Wen et al. 2012 (in East Asians) [7]

rs261966

PCSK1

5

G

A

1.03

0.87-1.22

0.764

rs12597579

GP2

16

C

T

1.02

0.84-1.24

0.871

  1. SNP alleles which are associated with obesity risk in Chinese children are highlighted in bold. Chr. Chromosome