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Table 2 List of 54 deregulated genes identified in infantile hemangioma, as reported by the seven studies included in the meta-analysis

From: Integrative meta-analysis identifies microRNA-regulated networks in infantile hemangioma

Gene symbol

Gene name

Gene function

Gene ID

Over-expressed

SMARCE1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

chromatin remodelling

6605

RGS5

Regulator of G-protein signaling 5

cell signaling

8490

CTAG2

Cancer/testis antigen 2

autoimmunogenic tumor antigen

30848

LTBP2

Latent transforming growth factor beta binding protein 2

cell growth and differentiation

4053

ANG

Angiogenin, ribonuclease, RNase A family, 5

cell growth and differentiation

283

IGF2

Insulin-like growth factor 2

cell growth and differentiation

3481

TBX2

T-box 2

transcription factor

6909

NOTCH3

Notch 3

cell fate and signalling

4854

HSD17B2

Hydroxysteroid (17-beta) dehydrogenase 2

uncharacterized

3294

TFPI2

Tissue factor pathway inhibitor 2

tumor supressor

7980

GNG11

Guanine nucleotide binding protein (G protein), gamma 11

cell signaling

2791

NID1

Nidogen 1

cell interactions

4811

COL4A1

Collagen, type IV, alpha 1

basement membrane/metabolism

1282

KDR

Kinase insert domain receptor (a type III receptor tyrosine kinase)

cell growth and differentiation

3791

FCGR2B

Fc fragment of IgG, low affinity IIb, receptor (CD32)

immunocomplex phagocytosis/antibody production regulation

2213

PLAGL1

Pleiomorphic adenoma gene-like 1

tumor supressor

5325

DLK1

Delta-like 1 homolog (Drosophila)

cell growth and differentiation

8788

JAM3

Junctional adhesion molecule 3

cell adhesion

83700

NID2

Nidogen 2 (osteonidogen)

cell adhesion

22795

MEOX2

Mesenchyme homeobox 2

myogenesis regulation

4223

GABRE

Gamma-aminobutyric acid (GABA) A receptor, epsilon

synaptic transmission

2564

CEACAM1

Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

cell adhesion

634

BET1

Bet1 golgi vesicular membrane trafficking protein

vesicular transport

10282

MXRA5

Matrix-remodelling associated 5

matrix remodelling

25878

IGFBP7

Insulin-like growth factor binding protein 7

cell growth and differentiation

3490

NETO2

Neuropilin (NRP) and tolloid (TLL)-like 2

cell signaling

81831

BAI3

Brain-specific angiogenesis inhibitor 3

angiogenesis

577

PLXDC1

Plexin domain containing 1

uncharacterized

57125

JAG1

Jagged 1

hematopoiesis

182

EDNRA

Endothelin receptor type A

cell signaling

1909

ICAM2

Intercellular adhesion molecule 2

cell adhesion

3384

NOTCH4

Notch 4

cell fate

4855

STAB1

Stabilin 1

cell growth and differentiation

23166

EPHB3

EPH receptor B3

cell signaling

2049

LPHN1

Latrophilin 1

cell adhesion/signal transduction

22859

NPR1

Natriuretic peptide receptor 1

cell signaling

4881

Under-expressed

GPR37

G protein-coupled receptor 37 (endothelin receptor type B-like)

cell signaling

2861

IGFBP3

Insulin-like growth factor binding protein 3

cell growth and differentiation

3486

FLT1

Fms-related tyrosine kinase 1

cell growth and differentiation

2321

PDGFRA

Platelet-derived growth factor receptor, alpha polypeptide

cell growth and differentiation

5156

TGFBR3

Transforming growth factor, beta receptor III

cell growth and differentiation

7049

LPAR1

Lysophosphatidic acid receptor 1

cell growth and differentiation

1902

IGFBP5

Insulin-like growth factor binding protein 5

cell growth and differentiation

3488

EDNRB

Endothelin receptor type B

cell signaling

1910

PDGFC

Platelet derived growth factor C

cell growth and differentiation

56034

BMP4

Bone morphogenetic protein 4

cell growth and differentiation

652

ANGPTL1

Angiopoietin-like 1

cell growth and differentiation

9068

VCAM1

Vascular cell adhesion molecule 1

cell adhesion

7412

BMP5

bone morphogenetic protein 5

cell growth and differentiation

653

IGF1R

Insulin-like growth factor 1 receptor

cell growth and differentiation

3480

ANGPT2

Angiopoietin 2

vascular remodeling

285

ANTXR1

Anthrax toxin receptor 1

cell signaling

84168

CLDN11

Claudin 11

cell adhesion

5010

KISS1

KiSS-1 metastasis-suppressor

cell adhesion

3814