Common variants in LEPR, IL6, AMD1, and NAMPT do not associate with risk of juvenile and childhood obesity in Danes: a case–control study

Table 4 Association with quantitative traits in 1761 overweight/obese individuals

SNP	Locus	Alleles (Effect/other)	Effect allele frequency	GOYA (n = 739)			TDCOB (n = 1022)			Combined (n = 1761)
SNP	Locus	Alleles (Effect/other)	Effect allele frequency	β	SE	p	β	SE	p	β	SE	p	I² (p_HET)
zBMI
rs2069845	IL6	G/A	0.48	0.02	0.09	0.78	0.01	0.03	0.90	0.01	0.03	0.84	0 (0.83)
rs1137100	LEPR	A/G	0.74	0.11	0.10	0.28	−0.01	0.03	0.71	0.01	0.03	0.99	20 (0.26)
rs3801266	NAMPT	T/C	0.83	−0.09	0.12	0.45	−0.05	0.04	0.19	−0.06	0.04	0.13	0 (0.77)
rs2796749	AMD1	G/C	0.78	−0.11	0.11	0.31	−0.06	0.04	0.08	−0.07	0.04	0.05	0 (0.69)
zHeight
rs2069845	IL6	G/A	0.48	0.04	0.05	0.39	−0.01	0.04	0.79	0.01	0.03	0.70	0 (0.41)
rs1137100	LEPR	A/G	0.74	0.05	0.05	0.35	−0.05	0.05	0.28	−0.01	0.04	0.89	49 (0.16)
rs3801266	NAMPT	T/C	0.83	−0.04	0.06	0.54	−0.02	0.06	0.70	−0.03	0.04	0.48	0 (0.85)
rs2796749	AMD1	G/C	0.78	0.05	0.06	0.43	−0.04	0.05	0.51	0.01	0.04	0.94	2 (0.31)
zWeight
rs2069845	IL6	G/A	0.48	0.07	0.09	0.41	−0.02	0.02	0.46	−0.01	0.02	0.61	0 (0.33)
rs1137100	LEPR	A/G	0.74	0.13	0.10	0.19	0.02	0.03	0.45	0.03	0.03	0.28	11 (0.28)
rs3801266	NAMPT	T/C	0.83	−0.11	0.11	0.33	0.03	0.03	0.38	0.02	0.03	0.54	24 (0.25)
rs2796749	AMD1	G/C	0.78	−0.03	0.11	0.75	0.02	0.03	0.56	0.01	0.03	0.63	0 (0.65)

Effect sizes (β), standard error (SE) and p-values are for an additive genetic model based on z-scores of each trait and is adjusted for age. Effect allele frequency is the mean frequency observed for the GOYA and TDCOB cohort obese individuals. P_add < 0.05 is significant. Values of I² are percentages
Add additive, BMI body mass index, CI confidence interval, HET heterogeneity, SE standard error, SNP single nucleotide polymorphism

ISSN: 1471-2350