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Table 3 Association with quantitative traits in 1372 normal weight individuals

From: Common variants in LEPR, IL6, AMD1, and NAMPT do not associate with risk of juvenile and childhood obesity in Danes: a case–control study

SNP

Locus

Alleles (effect/other)

Effect allele frequency

GOYA (n = 722)

TDCOB (n = 650)

Combined (n = 1372)

β

SE

p

β

SE

p

β

SE

p

I2 (p HET )

zBMI

 rs2069845

IL6

G/A

0.49

0.04

0.05

0.34

−0.02

0.05

0.62

0.01

0.04

0.76

3 (0.31)

 rs1137100

LEPR

A/G

0.74

−0.17

0.06

0.0036

−0.08

0.06

0.15

−0.12

0.04

0.0026

20 (0.26)

 rs3801266

NAMPT

T/C

0.83

−0.03

0.07

0.58

0.04

0.07

0.51

0.01

0.05

0.93

0 (0.39)

 rs2796749

AMD1

G/C

0.78

0.03

0.06

0.60

−0.16

0.06

0.0077

−0.06

0.04

0.12

80 (0.03)

zHeight

 rs2069845

IL6

G/A

0.49

0.02

0.05

0.65

−0.07

0.06

0.19

−0.02

0.04

0.56

36 (0.20)

 rs1137100

LEPR

A/G

0.74

0.01

0.06

0.63

−0.08

0.06

0.17

−0.04

0.04

0.36

5 (0.30)

 rs3801266

NAMPT

T/C

0.83

0.07

0.07

0.32

−0.12

0.08

0.12

−0.02

0.05

0.75

69 (0.07)

 rs2796749

AMD1

G/C

0.78

−0.12

0.06

0.046

0.10

0.07

0.15

−0.02

0.05

0.64

82 (0.01)

zWeight

 rs2069845

IL6

G/A

0.49

0.06

0.05

0.29

−0.05

0.03

0.047

−0.03

0.02

0.19

69 (0.06)

 rs1137100

LEPR

A/G

0.74

−0.14

0.06

0.017

−0.02

0.03

0.44

−0.05

0.03

0.08

68 (0.07)

 rs3801266

NAMPT

T/C

0.83

0.02

0.07

0.82

−0.01

0.04

0.79

−0.01

0.03

0.89

0 (0.75)

 rs2796749

AMD1

G/C

0.78

−0.07

0.06

0.29

−0.01

0.03

0.95

−0.01

0.03

0.66

0 (0.33)

  1. Effect sizes (β), standard error (SE) and p-values are for an additive genetic model based on z-scores of each trait and are adjusted for age. Effect allele frequency is the mean frequency observed for the GOYA and TDCOB cohort control individuals. P add  < 0.05 is significant and is shown in bold. Values of I2 are percentages
  2. BMI body mass index, CI confidence interval, HET heterogeneity, SE standard error, SNP single nucleotide polymorphism