Common variants in LEPR, IL6, AMD1, and NAMPT do not associate with risk of juvenile and childhood obesity in Danes: a case–control study

Table 2 Association with obesity: Case–control analysis in GOYA (male) and TDCOB study participants

SNP	Locus	Alleles (effect/other)	GOYA (n = 1461)				TDCOB (n = 1672)				Combined (n = 3133)
SNP	Locus	Alleles (effect/other)	n (cases/controls)	EAF (cases/controls)	p	OR (95 % CI)	n (cases/controls)	EAF (cases/controls)	p	OR (95 % CI)	n (cases/controls)	p	OR (95 % CI)	I² (p_HET)
rs2069845	IL6	G/A	739/722	0.49/0.49	0.88	0.98 (0.85–1.14)	1022/650	0.47/0.49	0.13	0.88 (0.76–1.01)	1761/1372	0.24	0.94 (0.85–1.04)	0 (0.35)
rs1137100	LEPR	A/G	739/722	0.74/0.74	0.69	0.96 (0.81–1.14)	1022/650	0.75/0.74	0.42	1.05 (0.90–1.23)	1761/1372	0.46	1.01 (0.90–1.14)	0 (0.40)
rs3801266	NAMPT	T/C	739/722	0.82/0.83	0.96	0.99 (0.82–1.20)	1022/650	0.83/0.84	0.47	0.92 (0.76–1.11)	1761/1372	0.58	0.96 (0.84–1.10)	0 (0.63)
rs2796749	AMD1	G/C	739/722	0.78/0.78	0.94	1.0 (0.84–1.19)	1022/650	0.79/0.78	0.59	1.03 (0.87–1.22)	1761/1372	0.68	1.02 (0.90–1.15)	7 (0.73)

Cases and controls were defined using age and sex-specific cut-offs corresponding to a BMI ≥25 kg/m² in adults. p-values are for an additive genetic model and are adjusted for age
EAF Effect allele frequency, BMI body mass index, CI confidence interval, HET heterogeneity, OR Odds Ratio, SNP single nucleotide polymorphism

ISSN: 1471-2350