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Table 3 Gene-based association analysis results

From: Genetic contribution of SCARB1 variants to lipid traits in African Blacks: a candidate gene association study

Trait

Variants

Test Statistics

P

Best SNP

(n)

SNP Namea-SNP IDb

MAF

P

HDL-C

136

207.5483

0.0421

p82264-rs141545424

0.0007

0.0016

LDL-C

136

134.1860

0.4640

p32777-rs11057841

0.2805

0.0047

TG

136

118.1598

0.6700

p86316-rs701104

0.0487

0.0357

ApoA-I

136

183.5565

0.1016

p55963-rs7134858

0.1560

0.0052

ApoB

136

143.7284

0.3760

p22116-rs12370382

0.0645

0.0153

  1. ApoA-I apolipoprotein A-I, ApoB apolipoprotein B, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, MAF minor allele frequency, SNP single nucleotide polymorphism, TG triglycerides
  2. All results were adjusted for covariates: sex, age, body mass index, waist, current smoking (yes/no), minutes of walking or biking to work each day (jobmin), and occupational status [staff: junior (non-professional staff)/senior (professional and administrative staff)]
  3. Nominally significant gene-based P-values (P < 0.05) are shown in bold
  4. aRefSeq of SCARB1: hg19, NM_005505 (CHIP Bioinformatics)
  5. bdbSNP build 139: GRCh37.p10