Genetic contribution of SCARB1 variants to lipid traits in African Blacks: a candidate gene association study

BMC Medical Genetics

Table 1 Characteristics and lipid profile of 95 individuals with extreme^a HDL-C levels and of the entire sample of 788 African Blacks

	95 Individuals with Extreme^a HDL-C Levels			The Entire Sample^b
Variables	High HDL-C Group	Low HDL-C Group	P ^d
Variables	(HDL-C range^c: 68.30–99.00 mg/dL)	(HDL-C range^c: 10.30–35.00 mg/dL)	P ^d
N (Females, n)	48 (24)	47 (24)	1.00	788 (293)
Age, years	41.29 ± 8.72	40.87 ± 7.12	0.80	40.95 ± 8.39
BMI, kg/m²	22.06 ± 4.70	23.91 ± 5.51	0.08	22.87 ± 4.04
Total Cholesterol, mg/dL	201.00 ± 39.68	141.68 ± 31.03	2.40E-12	172.01 ± 38.47
LDL-Cholesterol, mg/dL	112.55 ± 39.75	95.04 ± 28.28	0.02	109.25 ± 34.40
HDL-Cholesterol, mg/dL	76.05 ± 7.53	25.51 ± 5.66	2.20E-16	47.88 ± 12.87
Triglycerides, mg/dL	61.98 ± 19.85	95.79 ± 73.21	0.004	72.96 ± 39.32
Apolipoprotein A-I, mg/dL	166.04 ± 28.19	103.84 ± 27.23	2.20E-16	137.03 ± 28.46
Apolipoprotein B, mg/dL	66.00 ± 20.22	69.64 ± 21.46	0.40	66.98 ± 22.19

BMI body mass index, HDL-C/HDL-Cholesterol high-density lipoprotein cholesterol, LDL-Cholesterol low-density lipoprotein cholesterol
Values are presented as unadjusted means ± standard deviation (SD), unless otherwise mentioned
^aDistribution of HDL-C was adjusted for sex and age: HDL-C levels ≥90th % tile defined as the “High HDL-C group”, and HDL-C levels ≤10th % tile defined as the “Low HDL-C group”
^bAll data were unadjusted and included individuals with missing values or outliers (values beyond mean ± 3.5 SD)
^cUnadjusted range values
^dUnadjusted P-values were calculated with t-test or χ² test depending on types of variables

ISSN: 1471-2350