| | rs2855126 | rs2855123 |
|---|
Chromosome | 11 | 11 |
Position, bp | 5,273,147 | 5,277,078 |
Coded Allele | G | T |
Other Allele | C | A |
Ancestral Allele | C | A |
FreqHUFS | 0.247 | 0.246 |
FreqASW | 0.353 | 0.353 |
FreqCEU | 0.412 | 0.406 |
FreqYRI | 0.176 | 0.176 |
P
Allele
a
| 6.80 × 10−7 | 1.29 × 10−6 |
BetaMetab | −0.125 | −0.127 |
SEMetac | 0.0338 | 0.0341 |
P
Meta
d
| 2.27 × 10−4 | 1.99 × 10−4 |
P
Het
e
| 0.818 | 0.739 |
I2f | 0 | 0 |
- HUFS indicates the Howard University Family Study; ASW, Americans of African Ancestry in SW USA; CEU, Utah Residents (CEPH) with Northern and Western European ancestry; and YRI, Yoruba in Ibadan, Nigeria.
- aP-value from the test of allele frequencies from the stratum of 0 African chromosomes vs. 2 African chromosomes.
- bInverse variance-weighted effect size across the three ancestry strata. For rs2855126, the effect size corresponds to 0.357 mg/dL per allele.
- cInverse variance-weighted standard error across the three ancestry strata.
- dAssociation p-value for the effect size and standard error combined across the three ancestry strata.
- eP-value from Cochran’s Q test for heterogeneity in effect size across ancestry strata.
- fThe percentage of heterogeneity in effect size estimates due to between-strata heterogeneity.
