Table 1 Selected features from the Human miRNA disease database (HMDD) included in present study
From: Genetic association analysis of miRNA SNPs implicates MIR145 in breast cancer susceptibility
Selected diseases and/or pathological features related to breast cancer | |||
|---|---|---|---|
miRNA-disease association dataset | Human miRNA genes in dataset | 1. Adenocarcinoma | 5. Squamous Cell Carcinoma |
503 | 2. Breast Neoplasms | 6. Neoplasms | |
| Â | 3. Carcinoma | 7. Germ cell and embryonal neoplasm | |
Human Diseases in dataset | 4. Ductal breast carcinoma | 8. Squamous cell neoplasms | |
396 | Â | Â | |
Selected biological and/or cellular function in relation to Cancer | |||
miRNA function dataset | Human miRNA genes in dataset | Â | Â |
503 | 1. Activation of caspases cascade | 13. Cell proliferation | |
2. Akt pathway | 14. Chemosensitivity of tumour cells | ||
3. Angiogenesis | 15. Chemotaxis | ||
4. Anti-cell proliferation | 16. Chromatin remodelling | ||
5. Apoptosis | 17. DNA Repair | ||
6. Cell cycle related | 18. Epithelial-mesenchymal transition | ||
Biological and cellular functions in dataset | 7. Cell death | 19. Human embryonic stem cell (hESC) regulation | |
8. Cell differentiation | 20 Immune response | ||
9. Cell division | 21. Immune system | ||
10. Cell fate determination | 22. Inflammation | ||
43 | 11. Cell motility | 23 miRNA tumour suppressors | |
| Â | Â | 12. Cell proliferation | 24. Onco-miRNAs |