Table 1 Carrier frequencies for select super-populations in the 1000 Genomes dataset
Superpopulation (subpopulations) | Number of Samples | Number of Carriers (P(carrier) > 1/2) | Carrier frequency, pObs (95 % exact CI) | Published carrier frequency, p0 (95 % CI) | P-value |
|---|---|---|---|---|---|
(H0: pObs = p0) | |||||
Caucasian (CEU, FIN, GBR, IBS, TSI) | 503 | 13 | 0.026 (0.014 , 0.044) | 0.022 (0.020, 0.024) | 0.543 |
Black (ACB, ASW, ESN, GWD, LWK, MSL, YRI) | 661 | 4 | 0.006 (0.002, 0.015) | 0.014 (0.009, 0.018) | 0.095 |
Asian (CDX, CHB, CHS, JPT, KHV) | 502 | 6 | 0.012 (0.004, 0.026) | 0.020 (0.016, 0.024) | 0.261 |
Hispanic (MXL, PUR, CLM) | 261 | 6 | 0.023 (0.009, 0.049) | 0.012 (0.006, 0.017) | 0.140 |
Asian Indian (GIH, ITU, STU, BEB, PJL) | 489 | 3 | 0.006 (0.001, 0.018) | 0.020 (0.010, 0.029) | 0.022 |
All | 2501 | 36 | 0.01 (0.010, 0.020) | 0.019 (0.018, 0.020) | 0.138 |