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Table 3 Comparison of the metabolic parameters with MTTP genotypes

From: MTTP-297H polymorphism reduced serum cholesterol but increased risk of non-alcoholic fatty liver disease-a cross-sectional study

Genotype

BMI (kg/m2)

P

TG (mg/dl)

P

HOMA-IR

P

Adipo-IR

P

(promoter) G-493T

  

 GG+GT (n = 1155)

24.5 ± 3.3

0.527

138.3 ± 123.9

0.039*

1.09 ± 2.29

0.572

2.46 ± 3.84

0.014*

 TT (n = 29)

24.7 ± 2.5

 

117.1 ± 49.7

 

0.83 ± 0.72

 

1.61 ± 1.32

 

Glu98Asp (E98D)

  

 GG+GC (n = 1127)

24.5 ± 3.3

0.050*

137.0 ± 120.9

0.001*

1.09 ± 2.31

0.044*

2.48 ± 3.87

0.436

 CC (n = 25)

22.6 ± 2.3

 

101.3 ± 43.2

 

0.61 ± 1.02

 

1.78 ± 2.98

 

Ile128Thr (I128T)

  

 TT+TC (n = 1148)

24.5 ± 3.3

0.640

138.1 ± 123.6

0.040*

1.08 ± 2.29

0.140

2.46 ± 3.86

0.017*

 CC (n = 26)

24.8 ± 2.6

 

114.9 ± 51.9

 

0.833 ± 0.75

 

1.57 ± 1.38

 

Asn166Ser (N166S)

  

 AA+AG (n = 1145)

24.5 ± 3.3

0.006*

138.6 ± 123.9

0.001*

1.05 ± 1.92

0.301

2.43 ± 2.75

0.442

 GG (n = 24)

22.7 ± 2.3

 

102.8 ± 44.3

 

0.62 ± 1.04

 

1.77 ± 2.98

 

Gln297His (Q297H)

 GG+GC (n = 984)

24.5 ± 3.4

0.913

136.9 ± 124.1

0.656

1.09 ± 2.43

0.451

0.57 ± 0.23

0.337

 CC (n = 193)

24.5 ± 2.9

 

141.2 ± 116.2

 

0.92 ± 0.98

 

0.58 ± 0.25

 
  1. Data are shown as mean ± SD
  2. Independent t test was used for statistical analysis of body mass index (BMI) and insulin resistance (HOMA-IR and Adipo-IR)
  3. Mann–Whitney U test was used to analyze triglyceride (TG). (* P < 0.05 indicates significant)