Table 3 Allele and genotype frecuencies of five LOXL1 SNPs in Spanish individuals with XFG and controls
From: LOXL1 gene variants and their association with pseudoexfoliation glaucoma (XFG) in Spanish patients
SNP ID | XFG % (n = 105) | Control % (n = 200) | p value | OR (95 % CI) | |
|---|---|---|---|---|---|
rs16958477 | |||||
Allele | C | 57.6 | 41.2 | 0.0001 | 1.94 (1.20–3.13) |
A | 42.4 | 58.8 | 0.52 (0.32–0.83) | ||
Genotype | CC | 32.4 | 15.5 | 6.25x10−4 | 2.61 (1.49–4.57)* |
AC | 50.5 | 51.5 | 0.96 (0.60–1.54) | ||
AA | 17.1 | 33.0 | 0.42 (0.23–0.76) | ||
Total | 34/53/18 (CC/CA/AA) | 31/103/66 (CC/CA/AA) | 4.29x10−4 | ||
rs1048661 | |||||
Allele | G | 84.3 | 63.7 | 8.47x10−8 | 3.05 (1.67–5.55) |
T | 15.7 | 36.3 | 0.22 (0.11–0.43) | ||
Genotype | GG | 71.4 | 40.0 | 1.80x10−7 | 3.75 (2.25–6.24)* |
GT | 25.7 | 47.0 | 0.39 (0.23–0.66) | ||
TT | 2.9 | 13.0 | 0.42 (0.12–1.52) | ||
Total | 75/27/3 (GG/GT/TT) | 80/94/26 (GG/GT/TT) | 5.9x10−7 | ||
rs3825942 | |||||
Allele | G | 99.0 | 84.5 | 2.54x10−8 | 19.08 (2.57–141.84) |
A | 1.0 | 15.5 | 0.05 (0.01–0.39) | ||
Genotype | GG | 98.1 | 72.0 | 3x10−8 | 20.03 (4.78–83.94)* |
GA | 1.90 | 25.0 | 0.06 (0.02–0.246) | ||
AA | 0 | 3.0 | - | ||
Total | 103/2/0 (GG/GA/AA) | 144/50/6 (GG/GA/AA) | 2.4x10−7 | ||
rs2165241 | |||||
Allele | T | 80.5 | 46.50 | 6.30x10−16 | 4.74 (2.72–8.28) |
C | 19.5 | 53.50 | 0.21 (0.12–0.37) | ||
Genotype | TT | 66.7 | 20.50 | <0.01 | 7.76 (4.56–13.20)* |
CT | 27.6 | 52.00 | 0.35 (0.21–0.59) | ||
CC | 5.7 | 27.50 | 0.16 (0.06–0.39) | ||
Total | 70/29/6 (TT/TC/CC) | 41/104/55 (TT/TC/CC) | <0.01 | ||
rs3522 | |||||
Allele | C | 61.9 | 54.0 | 0.06 | 0.20 (0.11–0.38) |
T | 38.1 | 46.0 | 0.53 (0.32–0.85) | ||
Genotype | CC | 39.1 | 30.5 | 0.13 | 1.46 (0.89–2.39)* |
CT | 45.7 | 47.0 | 0.95 (0.59–1.53) | ||
TT | 15.2 | 22.5 | 0.62 (0.33–1.16) | ||
Total | 41/48/16 (CC/CT/TT) | 61/94/45 (CC/CT/TT) | 0.18 |