Table 1 Comparative data of LOXL1 risk alleles in different populations with XFS/XFG
From: LOXL1 gene variants and their association with pseudoexfoliation glaucoma (XFG) in Spanish patients
Population (Reference) | rs1048661 | rs3825942 | rs2165241 | |||
|---|---|---|---|---|---|---|
Risk allele | p value | Risk allele | p value | Risk allele | p value | |
Spanish (present study) | G | 8.47×10−8 | G | 2.54×10−8 | T | 6.30×10−16 |
Spanish [35] | No assoc. | 0.19 | G | 3.36×10−5 | T | 2.50×10−4 |
Icelandic [20] | G | 1.80×10−6 | G | 4.10×10−9 | T | 4.3×10−12 |
Swedish [20] | G | 2.70×10−7 | G | 9.10×10−14 | T | 3.1×10−17 |
Finnish [47] | G | 1.47×10−5 | G | 4.82×10−10 | T | 7.36×10−14 |
Austrian [57] | G | 2.55×10−7 | G | 5.76×10−15 | NA | NA |
German [48] | G | 4.32×10−16 | G | 1.21×10−11 | T | 6.77×10−30 |
Italian [48] | G | 0.0009 | G | 1.66×10−18 | T | 2.19×10−10 |
Polish [53] | No assoc. | 0.09 | G | 0.0047 | T | 0.021 |
Greek [52] | No assoc. | 0.490 | G | 1.56×10−5 | T | 0.016 |
Greek [58] | G | 0.0045 | G | 8.65×10−4 | NA | NA |
Greek [59] | No assoc. | 0.1226 | G | 0.0003 | NA | NA |
American and European [51] | G | 7.74×10−9 | G | 3.10×10−17 | T | 4.85×10−24 |
American [49] | G | 0.0222 | G | 0.0194 | T | 0.001 |
American [50] | G | 0.0031 | G | 1.3×10−13 | T | 1.50×10−5 |
American [60] | NA | NA | G | 4.53×10−5 | T | 1.09×10−8 |
Australian [61] | G | 8.49×10−4 | G | 7.83×10−5 | NA | NA |
Turkish [62] | G | 7.08×10−7 | G | 5.8×10−16 | NA | NA |
Pakistani [63] | G | 1×10−7 | G | 1×10−7 | NA | NA |
Saudi Arabian [36] | G | 0.0056 | G | 5×10−6 | NA | NA |
Mexican [64] | No assoc. | 0.71 | G | 0.0019 | T | 1×10−5 |
Uygur [65] | G | 0.013 | G | <0.001 | T | <0.001 |
Chinese [30] | No assoc. | 0.142 | G | 0.0018 | NA | NA |
Chinese (Uygur) [21] | T | 6.95×10−11 | G | 8×10−4 | C | 0.01 |
Indian [31] | No assoc. | 0.156 | G | 0.0001 | NA | NA |
South Indian [32] | G | 4.28×10−5 | G | 4.68×10−30 | T | 1.98×10−15 |
Japanese [22] | T | 7.70×10−18 | G | 4.10×10−4 | No assoc. | NA |
Japanese [23] | T | 3×10−19 | G | 1.4×10−5 | NA | NA |
Japanese [24] | T | <0.0001 | G | <0.0001 | NA | NA |
Japanese [25] | T | <1×10−8 | G | 7×10−8 | NA | NA |
Japanese [26] | T | 6.41×10−48 | G | 1.30×10−11 | C | 2.31×10−7 |
Japanese [27] | T | 5.65×10−33 | G | 2.42×10−22 | C | 7.87×10−7 |
Korean [28] | T | 2.13×10−12 | G | 9.12×10−6 | C | 2.59×10−3 |
Korean [29] | T | 5.74×10−12 | G | 0.0003 | C | 0.0011 |
Black South African [33] | G | 0.00106 | A | <0.00001 | NA | NA |
Black South African [34] | G | 1.7×10−5 | A | 5.2×10−13 | NA | NA |