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Table 2 Associations between T2DM and 3′ UTR SNPs of susceptibility genes for T2DM

From: Polymorphism in microRNA-binding site in HNF1B influences the susceptibility of type 2 diabetes mellitus: a population based case–control study

Gene SNP Predicted interacting miRNA Genotype T2DM n (%) Control n (%) OR (95%CI) P-value Power
SLC30A8 rs11558471 hsa-miR-1205 AA 130 (37.3) 135 (30.7) 1 (Reference) 0.022 0.78
   hsa-miR-1248 AG 168 (48.1) 229 (52.1) 0.78 (0.62–0.96)   
   hsa-miR-3074-5p GG 51 (14.6) 76(17.3) 0.60 (0.39–0.93)   
  rs3802178 hsa-miR-1234-3p AA 145 (41.6) 215 (48.4) 1 (Reference) 0.10 0.74
    GA 169 (48.4) 187 (42.1) 1.21 (0.96–1.51)   
    GG 35 (10.0) 42 (9.5) 1.46 (0.93–2.30)   
  rs2466295 hsa-miR -586 TT 275 (77.9) 341 (76.8) 1 (Reference) 0.67 0.52
    TC 71 (20.1) 91 (20.5) 0.94 (0.69–1.27)   
    CC 7 (2.0) 12 (2.7) 0.88 (0.48–1.60   
  rs2466293 hsa-miR- 181a-2-3p TT 95 (27.3) 145 (33.2) 1 (Reference) 0.11 0.78
   hsa-miR-660-5p TC 181 (52.0) 203 (46.5) 1.19 (0.96–1.47)   
   hsa-miR-888-3p CC 72 (20.7) 89 (20.4) 1.41 (0.93–2.15)   
   hsa-miR-1273d       
HNF1B rs2229295 hsa-miR214-5p CC 278 (78.7) 308 (68.8) 1 (Reference) 0.004 0.61
   hsa-miR550a-5p CA 66 (18.7) 121 (27) 0.66 (0.50–0.88)   
   hsa-miR550a-3-5p AA 9 (2.6) 19 (4.2) 0.44 (0.25–0.77)   
   hsa-miR1271-3p       
  rs1800929 hsa-miR214-5p AA 238 (67.4) 285 (63.6) 1 (Reference) 0.071 0.65
   hsa-miR550a-5p AG 100 (28.3) 142 (31.7) 0.79 (0.60–1.02)   
   hsa-miR550a-3-5p GG 15 (4.3) 21 (4.7) 0.62 (0.37–1.04)   
   hsa-miR1271-3p       
CDC123 rs10951 hsa-miR-145-5p GG 169 (53.5) 249 (60.9) 1 (Reference) 0.027 0.65
   hsa-miR-770-5p GA 134 (42.4) 147 (35.9) 1.36 (1.04–1.79)   
   hsa-miR-4712-5p AA 13 (4.1) 13 (3.2) 1.86 (1.07–3.22)   
PPARGC1A rs6821591 hsa-miR-187-3p TT 180 (55.7) 200 (48.7) 1 (Reference) 0.13 0.73
   hsa-miR-595 TC 120 (37.2) 180 (43.8) 0.83 (0.65–1.06)   
    CC 23 (7.1) 31 (7.5) 0.69 (0.42–1.12)   
UBE2E2 rs7631705 hsa-miR-888-3p TT 155 (47.8) 165 (42.5) 1 (Reference) 0.018 0.76
   hsa-miR-3660 TC 143 (44.1) 170 (43.8) 0.75 (0.59–0.95)   
   hsa-miR-4526 CC 26 (8.0) 53 (13.7) 0.57 (0.35–0.91)   
IRS2 rs2289047 hsa-miR-376c-3p GG 103 (29.6) 141 (32.3) 1 (Reference) 0.22 0.78
    GT 163 (46.8) 215 (49.3) 1.14 (0.92–1.40)   
    TT 82 (23.6) 80 (18.4) 1.29 (0.85–1.96)   
SPRY2 rs1644394 hsa-miR-1224-3p TT 199 (57.0) 255 (58.5) 1 (Reference) 0.77 0.69
   hsa-miR-1260a TG 124 (35.5) 146 (33.5) 0.97 (0.77–1.22)   
   hsa-miR-1260b GG 26 (7.5) 35 (8.0) 0.93 (0.59–1.48)   
   hsa-miR-4733-5p       
  1. Odd ratios and P - values were adjusted by age and BMI
  2. Statistically significant P - value after Bonferroni correction was indicated in bold
  3. Power to detect association was estimated under current sample size and minor allele frequency, assuming OR = 1.2 and additive effect