Table 2 Associations between T2DM and 3′ UTR SNPs of susceptibility genes for T2DM
Gene | SNP | Predicted interacting miRNA | Genotype | T2DM n (%) | Control n (%) | OR (95%CI) | P-value | Power |
|---|---|---|---|---|---|---|---|---|
SLC30A8 | rs11558471 | hsa-miR-1205 | AA | 130 (37.3) | 135 (30.7) | 1 (Reference) | 0.022 | 0.78 |
hsa-miR-1248 | AG | 168 (48.1) | 229 (52.1) | 0.78 (0.62–0.96) | ||||
hsa-miR-3074-5p | GG | 51 (14.6) | 76(17.3) | 0.60 (0.39–0.93) | ||||
rs3802178 | hsa-miR-1234-3p | AA | 145 (41.6) | 215 (48.4) | 1 (Reference) | 0.10 | 0.74 | |
GA | 169 (48.4) | 187 (42.1) | 1.21 (0.96–1.51) | |||||
GG | 35 (10.0) | 42 (9.5) | 1.46 (0.93–2.30) | |||||
rs2466295 | hsa-miR -586 | TT | 275 (77.9) | 341 (76.8) | 1 (Reference) | 0.67 | 0.52 | |
TC | 71 (20.1) | 91 (20.5) | 0.94 (0.69–1.27) | |||||
CC | 7 (2.0) | 12 (2.7) | 0.88 (0.48–1.60 | |||||
rs2466293 | hsa-miR- 181a-2-3p | TT | 95 (27.3) | 145 (33.2) | 1 (Reference) | 0.11 | 0.78 | |
hsa-miR-660-5p | TC | 181 (52.0) | 203 (46.5) | 1.19 (0.96–1.47) | ||||
hsa-miR-888-3p | CC | 72 (20.7) | 89 (20.4) | 1.41 (0.93–2.15) | ||||
hsa-miR-1273d | ||||||||
HNF1B | rs2229295 | hsa-miR214-5p | CC | 278 (78.7) | 308 (68.8) | 1 (Reference) | 0.004 | 0.61 |
hsa-miR550a-5p | CA | 66 (18.7) | 121 (27) | 0.66 (0.50–0.88) | ||||
hsa-miR550a-3-5p | AA | 9 (2.6) | 19 (4.2) | 0.44 (0.25–0.77) | ||||
hsa-miR1271-3p | ||||||||
rs1800929 | hsa-miR214-5p | AA | 238 (67.4) | 285 (63.6) | 1 (Reference) | 0.071 | 0.65 | |
hsa-miR550a-5p | AG | 100 (28.3) | 142 (31.7) | 0.79 (0.60–1.02) | ||||
hsa-miR550a-3-5p | GG | 15 (4.3) | 21 (4.7) | 0.62 (0.37–1.04) | ||||
hsa-miR1271-3p | ||||||||
CDC123 | rs10951 | hsa-miR-145-5p | GG | 169 (53.5) | 249 (60.9) | 1 (Reference) | 0.027 | 0.65 |
hsa-miR-770-5p | GA | 134 (42.4) | 147 (35.9) | 1.36 (1.04–1.79) | ||||
hsa-miR-4712-5p | AA | 13 (4.1) | 13 (3.2) | 1.86 (1.07–3.22) | ||||
PPARGC1A | rs6821591 | hsa-miR-187-3p | TT | 180 (55.7) | 200 (48.7) | 1 (Reference) | 0.13 | 0.73 |
hsa-miR-595 | TC | 120 (37.2) | 180 (43.8) | 0.83 (0.65–1.06) | ||||
CC | 23 (7.1) | 31 (7.5) | 0.69 (0.42–1.12) | |||||
UBE2E2 | rs7631705 | hsa-miR-888-3p | TT | 155 (47.8) | 165 (42.5) | 1 (Reference) | 0.018 | 0.76 |
hsa-miR-3660 | TC | 143 (44.1) | 170 (43.8) | 0.75 (0.59–0.95) | ||||
hsa-miR-4526 | CC | 26 (8.0) | 53 (13.7) | 0.57 (0.35–0.91) | ||||
IRS2 | rs2289047 | hsa-miR-376c-3p | GG | 103 (29.6) | 141 (32.3) | 1 (Reference) | 0.22 | 0.78 |
GT | 163 (46.8) | 215 (49.3) | 1.14 (0.92–1.40) | |||||
TT | 82 (23.6) | 80 (18.4) | 1.29 (0.85–1.96) | |||||
SPRY2 | rs1644394 | hsa-miR-1224-3p | TT | 199 (57.0) | 255 (58.5) | 1 (Reference) | 0.77 | 0.69 |
hsa-miR-1260a | TG | 124 (35.5) | 146 (33.5) | 0.97 (0.77–1.22) | ||||
hsa-miR-1260b | GG | 26 (7.5) | 35 (8.0) | 0.93 (0.59–1.48) | ||||
hsa-miR-4733-5p |