Table 5 GMDR results of multi-locus interaction with BM compared with the control group

AADAT T/_

0.6305

9 (0.0107)^*

9/10

APEX1 Glu/_, AADAT T/_

0.6359

9 (0.0107)^*

9/10

IL8 T/_,APEX1 Glu/_, AADAT T/_

0.6586

10 (0.0010)^*

10/10

IL8 T/_,APEX1 Glu/_, OGG1 Cys/_, AADAT T/_

0.5743

6 (0.3770)

6/10

IL8 T/_,APEX1 Glu/_, OGG1 Cys/_, PARP1 Ala/_,AADAT T/_

0.6302

9 (0.0107)^*

10/10

Best model (DNA repair enzymes)

Testing balanced accuracy

Sign test (P-value)

Cross-validation accuracy

APEX1 Glu/_

0.6605

9 (0.0107)^*

10/10

APEX1 Glu/_, OGG1 Cys/_,

0.5850

9 (0.0107)^*

8/10

APEX1 Glu/_, OGG1 Cys/_, PARP1 Ala/_,

0.6510

8 (0.0547)

10/10

Best model (protection SNPs)

Testing balanced accuracy

Sign test (P-value)

Cross-validation accuracy

TNF-308 A/_

0.5939

9 (0.0107)^*

10/10

TNF-308 A/_, TNF-857 T_

0.5758

8 (0.0547)

10/10

Best model (susceptibility alleles)

Testing balanced accuracy

Sign test (P-value)

Cross-validation accuracy

TNF-308 GG, AADAT T/_

0.6267

8 (0.0547)

7/10

TNF-308 GG, AADAT T/_, APEX1 Glu/_,IL8 T/_,

0.6108

9 (0.0107)^*

7/10

TNF-308 GG, AADAT T/_, APEX1 Glu/_, IL8 T/_, OGG1 Cys/_

0.5528

7 (0.1719)

5/10

TNF-308 GG, AADAT T/_, APEX1 Glu/_, IL8 T/_, OGG1 Cys/_, PARP1 Ala/_,

0.5553

7 (0.1719)

10/10