Genetic polymorphisms associated with the inflammatory response in bacterial meningitis

BMC Medical Genetics

Table 4 Genotypic frequencies of the SNPs for BM compared with the control group

Genotypes and alleles	Control group n (%)	BM group n (%)	P for difference	OR (95 % CI)	Adjusted P for difference^a	Adjusted OR (95 % CI) ^a
TNF −308	(controls = 109; cases = 54)
GG	69 (63)	46 (85)	0.020*	1	0.030*	1
GA	36 (33)	7 (13)		0.292 (0.12-0.711)		0.319 (0.129-0.790)
AA	4 (4)	1 (2)		0.375 (0.041-0.711)		0.311 (0.033-2.943)
TNF −857	(controls = 107; cases = 52)
CC	81 (76)	39 (75)	0.92	1	0.92	1
CT	26 (24)	13 (25)		1.038 (0.482-2.237)		1.475 (0.475-2.290)
TT	0 (0)	0 (0)
IL8 -251	(controls = 106; cases = 52)
AA	31 (29)	12 (23)	0.62	1	0.68	1
AT	43 (41)	25 (48)		1.502 (0.656-3.44)		1.398 (0.596-3.280)
TT	32 (30)	15 (29)		1.211 (0.490-3.00)		1.058 (0.416-2.690)

BM bacterial meningitis, OR odds ratio, CI confidence interval. Data analyzed by multivariate logistic regression analyses. ^*Statistical significance (P < 0.05). The reference group in each of the analyses was the most prevalent genotype. ^aData adjusted for age and gender

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