Fig. 2

a-d. Single voxel short TE (35 ms) 1H-MRS acquired from posterior centrum semiovale (WM) and interhemispheric parieto-occipital gray matter (GM) at 19 years (a-b). Single voxel short TE (35 ms) 1H MRS acquired from posterior centrum semiovale (WM) and interhemispheric parieto-occipital (GM) at 19 years (a - b); a comparison with the first 1H-MRS acquisition (7 years) was shown (c-d). In WM was present a decreased Choline (Cho) that is slightly reduced also in GM; no changes in proton MRS have been observed over the time