Fig 5

Human Leukocyte Antigen Alleles associated with multiple sclerosis in Ashkenazi Jews. A step-wise conditional analysis was performed to evaluate statistically significant independent HLA effects. Panel a left: SNPs from across MHC class I and class II passed the Bonferroni threshold of 0.05 (red line on figure), the top hit coming from class II near DRB1 and DQB1. Panel a right: The top significant HLA allele came from the HLA-C gene and was the *12:03 allele. Panel b: In the second analysis, HLA-C*12:03 was included as a covariate. Here again a handful of SNPs passed the Bonferroni threshold, and the top significant finding was at the HLA-A gene, where the *68:02 allele was most significant. Panel c: In the third analysis, HLA-C*12:03 and HLA-A*68:02 were both included as covariates. Here 3 SNPs passed the Bonferroni cutoff, and the top finding was the *15:01 allele at HLA-DRB1. Panel d: In the fourth analysis, the covariates were HLA-C*12:03, HLA-A*68:02, and HLA-DRB1*15:01 and no further statistically significant associations were seen