Table 6 Empirical power estimates for scenario 2 when h2 is 0.5. The empirical power estimates for scenario 2 were calculated with 1000 replicates at the both 0.1 and 0.001 significance levels. The disease allele frequency was assumed to be 0.2, and the prevalence was assumed to 0.2. The relative phenotypic variance attributable to the main disease gene was assumed to be 0.005
From: Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families
| Â | n proband | Statistic | N | |||
|---|---|---|---|---|---|---|
100 | 300 | 600 | 900 | |||
0.01 | 1 | WL | 0.130 | 0.293 | 0.567 | 0.787 |
FQLS 1 | 0.130 | 0.295 | 0.568 | 0.773 | ||
FQLS 2 | 0.140 | 0.323 | 0.603 | 0.823 | ||
2 | WL | 0.093 | 0.332 | 0.645 | 0.864 | |
FQLS 1 | 0.094 | 0.357 | 0.654 | 0.871 | ||
FQLS 2 | 0.108 | 0.354 | 0.694 | 0.902 | ||
3 | WL | 0.100 | 0.382 | 0.735 | 0.904 | |
FQLS 1 | 0.108 | 0.406 | 0.751 | 0.915 | ||
FQLS 2 | 0.130 | 0.408 | 0.772 | 0.932 | ||
0.001 | 1 | WL | 0.046 | 0.148 | 0.341 | 0.560 |
FQLS 1 | 0.050 | 0.149 | 0.353 | 0.559 | ||
FQLS 2 | 0.047 | 0.166 | 0.386 | 0.617 | ||
2 | WL | 0.019 | 0.127 | 0.387 | 0.634 | |
FQLS 1 | 0.021 | 0.119 | 0.394 | 0.648 | ||
FQLS 2 | 0.017 | 0.144 | 0.432 | 0.695 | ||
3 | WL | 0.023 | 0.166 | 0.481 | 0.749 | |
FQLS 1 | 0.026 | 0.183 | 0.511 | 0.772 | ||
FQLS 2 | 0.028 | 0.196 | 0.532 | 0.782 | ||