BMC Medical Genetics

Table 4 Empirical power estimates for scenario 1 when h² is 0.8. The empirical power estimates for scenario 1 were calculated with 1000 replicates at the both 0.01 and 0.001 significance levels. The disease allele frequency was assumed to be 0.2, and the prevalence was assumed to 0.2. The relative phenotypic variance attributable to the main disease gene was assumed to be 0.005

From: Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families

	n _proband	Statistic	N
	n _proband	Statistic	100	300	600	900	1200	1400
0.01	1	WL	0.068	0.233	0.470	0.699	0.819	0.903
		FQLS ₁	0.071	0.238	0.471	0.717	0.841	0.896
		FQLS ₂	0.078	0.298	0.559	0.817	0.899	0.943
	2	WL	0.071	0.222	0.521	0.708	0.881	0.937
		FQLS ₁	0.080	0.304	0.568	0.788	0.907	0.942
		FQLS ₂	0.085	0.311	0.605	0.830	0.930	0.948
	3	WL	0.075	0.253	0.555	0.786	0.911	0.931
		FQLS ₁	0.079	0.298	0.592	0.813	0.921	0.972
		FQLS ₂	0.078	0.311	0.629	0.823	0.941	0.982
	4	WL	0.081	0.307	0.585	0.800	0.917	0.951
		FQLS ₁	0.088	0.325	0.622	0.828	0.928	0.957
		FQLS ₂	0.092	0.318	0.614	0.832	0.929	0.962
0.001	1	WL	0.016	0.074	0.229	0.444	0.602	0.710
		FQLS ₁	0.017	0.072	0.221	0.436	0.643	0.693
		FQLS ₂	0.021	0.120	0.309	0.573	0.739	0.820
	2	WL	0.020	0.074	0.251	0.436	0.676	0.778
		FQLS ₁	0.017	0.103	0.313	0.540	0740	0.798
		FQLS ₂	0.024	0.116	0.350	0.589	0.782	0.845
	3	WL	0.024	0.081	0.278	0.513	0.734	0.810
		FQLS ₁	0.016	0.124	0.341	0.581	0.769	0.864
		FQLS ₂	0.017	0.129	0.365	0.604	0.802	0.881
	4	WL	0.015	0.109	0.310	0.542	0.756	0.830
		FQLS ₁	0.021	0.118	0.335	0.588	0.783	0.867
		FQLS ₂	0.021	0.133	0.345	0.597	0.790	0.874

The bold text indicates the highest empirical estimate of the power for each situation

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