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Table 6 TERT sequence variation and all-cause mortality. ARIC study (1987 – 2011)

From: Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study

  African-American (N = 3,319) (Deaths = 1,203) White (N = 9,827) (Deaths = 2,875)
  Model 1 Model 2 Model 1 Model 2
dbSNP ID HRR 95 % CI p HRR 95 % CI p HRR 95 % CI p HRR 95 % CI p
rs2736122             
Mortality 1.05 0.95, 1.15 0.36 1.04 0.94, 1.14 0.47 1.04 0.98, 1.10 0.22 1.03 0.97, 1.10 0.27
rs4246742             
Mortality 0.99 0.91, 1.08 0.85 0.99 0.90, 1.08 0.76 1.01 0.94, 1.08 0.80 1.02 0.95, 1.09 0.63
rs6863494             
Mortality 1.00 0.84, 1.20 0.96 1.00 0.84, 1.20 0.96 --    --   
rs4975605             
Mortality 0.96 0.89, 1.04 0.37 0.94 0.87, 1.02 0.16 1.00 0.95, 1.05 0.96 0.99 0.94, 1.04 0.74
rs2736100             
Mortality 1.00 0.92, 1.09 0.93 0.98 0.90, 1.07 0.73 1.03 0.98, 1.09 0.21 1.03 0.97, 1.08 0.32
rs2853668*             
Mortality 1.00 0.92, 1.09 0.94 0.97 0.89, 1.05 0.44 0.99 0.93, 1.05 0.73 1.02 0.96, 1.08 0.62
  1. dbSNP, The National Center for Biotechnology Information’s SNP database; SNP, single nucleotide polymorphism; ID, identification; N, number; HRR, hazard rate ratio; CI, confidence interval; p, p-value for hazard rate ratios from Cox regression models; Model 1, adjusted for age and gender; Model 2, adjusted for age, gender, BMI, current smoking, diabetes, hypertension, HDL cholesterol, LDL cholesterol; * not consistent with proportional hazards assumptions in whites for rs2853668 (Model 1)