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Table 6 TERT sequence variation and all-cause mortality. ARIC study (1987 – 2011)

From: Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study

 

African-American (N = 3,319) (Deaths = 1,203)

White (N = 9,827) (Deaths = 2,875)

 

Model 1

Model 2

Model 1

Model 2

dbSNP ID

HRR

95 % CI

p

HRR

95 % CI

p

HRR

95 % CI

p

HRR

95 % CI

p

rs2736122

            

Mortality

1.05

0.95, 1.15

0.36

1.04

0.94, 1.14

0.47

1.04

0.98, 1.10

0.22

1.03

0.97, 1.10

0.27

rs4246742

            

Mortality

0.99

0.91, 1.08

0.85

0.99

0.90, 1.08

0.76

1.01

0.94, 1.08

0.80

1.02

0.95, 1.09

0.63

rs6863494

            

Mortality

1.00

0.84, 1.20

0.96

1.00

0.84, 1.20

0.96

--

  

--

  

rs4975605

            

Mortality

0.96

0.89, 1.04

0.37

0.94

0.87, 1.02

0.16

1.00

0.95, 1.05

0.96

0.99

0.94, 1.04

0.74

rs2736100

            

Mortality

1.00

0.92, 1.09

0.93

0.98

0.90, 1.07

0.73

1.03

0.98, 1.09

0.21

1.03

0.97, 1.08

0.32

rs2853668*

            

Mortality

1.00

0.92, 1.09

0.94

0.97

0.89, 1.05

0.44

0.99

0.93, 1.05

0.73

1.02

0.96, 1.08

0.62

  1. dbSNP, The National Center for Biotechnology Information’s SNP database; SNP, single nucleotide polymorphism; ID, identification; N, number; HRR, hazard rate ratio; CI, confidence interval; p, p-value for hazard rate ratios from Cox regression models; Model 1, adjusted for age and gender; Model 2, adjusted for age, gender, BMI, current smoking, diabetes, hypertension, HDL cholesterol, LDL cholesterol; * not consistent with proportional hazards assumptions in whites for rs2853668 (Model 1)