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Table 5 TERT sequence variation and incident ischemic stroke. ARIC study (1987 – 2011)

From: Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study

  African-American (N = 3,022) (Ischemic Stroke = 287) White (N = 8,987 ) (Ischemic Stroke = 452)
  Model 1 Model 2 Model 1 Model 2
dbSNP ID HRR 95 % CI p HRR 95 % CI p HRR 95 % CI p HRR 95 % CI p
rs2736122             
Isch. stroke 0.89 0.73, 1.08 0.24 0.90 0.74, 1.10 0.32 1.01 0.87, 1.17 0.89 1.02 0.87, 1.18 0.82
rs4246742             
Isch. stroke 0.94 0.79, 1.11 0.47 0.96 0.80, 1.15 0.67 0.99 0.82, 1.18 0.89 1.00 0.83, 1.21 0.99
rs6863494             
Isch. stroke 0.90 0.61, 1.33 0.59 0.96 0.65, 1.42 0.84 --    --   
rs4975605             
Isch. stroke 0.94 0.80, 1.11 0.48 0.88 0.74, 1.04 0.14 1.00 0.88, 1.14 0.97 1.00 0.87, 1.14 0.98
rs2736100             
Isch. stroke 1.07 0.91, 1.27 0.41 1.03 0.86, 1.22 0.75 0.93 0.82, 1.06 0.31 0.93 0.81, 1.06 0.27
rs2853668             
Isch. stroke 1.17 1.00, 1.38 0.05 1.08 0.91, 1.28 0.36 1.02 0.88, 1.18 0.76 1.03 0.89, 1.20 0.71
  1. dbSNP, The National Center for Biotechnology Information’s SNP database; SNP, single nucleotide polymorphism; ID, identification; N, number; HRR, hazard rate ratio; CI, confidence interval; p, p-value for hazard rate ratios from Cox regression models; Model 1, adjusted for age and gender; Model 2, adjusted for age, gender, BMI, current smoking, diabetes, hypertension, HDL cholesterol, LDL cholesterol; Isch., ischemic