Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study

Table 5 TERT sequence variation and incident ischemic stroke. ARIC study (1987 – 2011)

	African-American (N = 3,022) (Ischemic Stroke = 287)						White (N = 8,987 ) (Ischemic Stroke = 452)
	Model 1			Model 2			Model 1			Model 2
dbSNP ID	HRR	95 % CI	p	HRR	95 % CI	p	HRR	95 % CI	p	HRR	95 % CI	p
rs2736122
Isch. stroke	0.89	0.73, 1.08	0.24	0.90	0.74, 1.10	0.32	1.01	0.87, 1.17	0.89	1.02	0.87, 1.18	0.82
rs4246742
Isch. stroke	0.94	0.79, 1.11	0.47	0.96	0.80, 1.15	0.67	0.99	0.82, 1.18	0.89	1.00	0.83, 1.21	0.99
rs6863494
Isch. stroke	0.90	0.61, 1.33	0.59	0.96	0.65, 1.42	0.84	--			--
rs4975605
Isch. stroke	0.94	0.80, 1.11	0.48	0.88	0.74, 1.04	0.14	1.00	0.88, 1.14	0.97	1.00	0.87, 1.14	0.98
rs2736100
Isch. stroke	1.07	0.91, 1.27	0.41	1.03	0.86, 1.22	0.75	0.93	0.82, 1.06	0.31	0.93	0.81, 1.06	0.27
rs2853668
Isch. stroke	1.17	1.00, 1.38	0.05	1.08	0.91, 1.28	0.36	1.02	0.88, 1.18	0.76	1.03	0.89, 1.20	0.71

dbSNP, The National Center for Biotechnology Information’s SNP database; SNP, single nucleotide polymorphism; ID, identification; N, number; HRR, hazard rate ratio; CI, confidence interval; p, p-value for hazard rate ratios from Cox regression models; Model 1, adjusted for age and gender; Model 2, adjusted for age, gender, BMI, current smoking, diabetes, hypertension, HDL cholesterol, LDL cholesterol; Isch., ischemic

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