Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study

Table 4 TERT sequence variation and incident coronary heart disease. ARIC study (1987 – 2011)

	African-American (N = 3,022) (MI/Fatal CHD = 403)						White (N = 8,987) (MI/Fatal CHD =933)
	Model 1			Model 2			Model 1			Model 2
dbSNP ID	HRR	95 % CI	p	HRR	95 % CI	p	HRR	95 % CI	p	HRR	95 % CI	p
rs2736122*
CHD	1.20	1.03, 1.40	0.02	1.18	1.01, 1.39	0.04	0.95	0.86, 1.06	0.38	0.94	0.85, 1.05	0.29
rs4246742*
CHD	1.00	0.87, 1.15	0.97	0.98	0.85, 1.14	0.83	0.96	0.85, 1.09	0.56	0.99	0.87, 1.13	0.88
rs6863494
CHD	0.93	0.67,1.29	0.66	0.95	0.68, 1.32	0.77	--			--
rs4975605
CHD	1.04	0.91, 1.19	0.55	1.05	0.91, 1.20	0.52	1.02	0.94, 1.12	0.61	1.02	0.93, 1.11	0.74
rs2736100
CHD	0.99	0.86, 1.14	0.89	1.00	0.86, 1.15	0.97	0.97	0.88, 1.06	0.48	0.98	0.89, 1.07	0.60
rs2853668
CHD	0.93	0.81, 1.07	0.32	0.98	0.84, 1.13	0.73	1.05	0.95, 1.16	0.35	1.07	0.97, 1.19	0.19

dbSNP, The National Center for Biotechnology Information’s SNP database; SNP, single nucleotide polymorphism; ID, identification; N, number; HRR, hazard rate ratio; CI, confidence interval; p, p-value for hazard rate ratios from Cox regression models; MI, myocardial infarction; CHD, coronary heart disease; Model 1, adjusted for age and gender; Model 2, adjusted for age, gender, BMI, current smoking, diabetes, hypertension, HDL cholesterol, and LDL cholesterol; *not consistent with proportional hazards assumptions in whites for rs2736122 (Model 1) and rs4246742 (Models 1 and 2)

ISSN: 1471-2350