Table 2 Distribution of gene variants retained after the manual backward elimination for lifetime smokeless tobacco use (Panel A), and comparison of gene variants retained after the manual backward elimination between HapMap and MATCh samples (Panel B)
| Â | Â | Panel A | Panel B | |||
|---|---|---|---|---|---|---|
Smokeless Tobacco Use | HapMap | MATCh | ||||
Genes | Dominant | Never | Ever | Â | minor allele | minor allele |
Model | (N = 1,025) | (N = 62) | ||||
| Â | N (%) | N (%) | N (%) | p-value | % | % |
SERGEF (rs2023902) | Â | Â | Â | 0.005 | Â | Â |
 0 | 856 (78.7) | 816 (79.6) | 40 (64.5) |  | 0.120 | 0.108 |
 1 | 209 (21.3) | 209 (20.4) | 22 (35.5) |  |  |  |
TPH1 (rs17721739) | Â | Â | Â | 0.002 | Â | Â |
 0 | 811 (74.6) | 775 (75.6) | 34 (54.8) |  | -- | 0.130 |
 1 | 276 (25.4) | 250 (24.4) | 28 (45.2) |  |  |  |
TRH-DE (rs514912) | Â | Â | Â | <0.001 | Â | Â |
 0 | 428 (39.4) | 419 (40.9) | 9 (14.5) |  | 0.360 | 0.386 |
 1 | 659 (60.6) | 606 (59.1) | 53 (85.5) |  |  |  |
ALDH2 (rs16941667) | Â | Â | Â | 0.002 | Â | Â |
 0 | 970 (89.2) | 922 (90.0) | 48 (77.4) |  | 0.050 | 0.057 |
 1 | 1,117 (10.8) | 103 (10.0) | 14 (22.6) |  |  |  |
SCL6A4 (rs4251417) | Â | Â | Â | 0.001 | Â | Â |
 0 | 1,017 (93.6) | 965 (94.1) | 52 (83.9) |  | 0.030 | 0.034 |
 1 | 70 (6.4) | 60 (5.9) | 10 (14.3) |  |  |  |