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Table 3 Pearson correlation coefficients between low-density lipoprotein cholesterol (LDL-C) levels, LEP mRNA and LEP gene CpG17 DNA methylation levels in subcutaneous adipose tissue (SAT) according to the rs2167270 genotype

From: Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women

 

LEP mRNA levels

LEP -CpG17 DNA methylation levels

 

ALL

GG

GA/AA

ALL

GG

GA/AA

 

n = 73

n = 30

n = 43

n = 73

n = 30

n = 43

LDL-C levels

−0.097

0.142

−0.317*

0.370**

0.400*

0.384**

Adjusted for sex and waist girth

LDL-C levels

−0.035

0.138

−0.205

-

-

-

Adjusted for sex, waist girth and LEP-CpG17 DNA methylation levels

LDL-C levels

-

-

-

0.360**

0.399*

0.303

Adjusted for sex, waist girth and LEP mRNA levels

LEP -CpG17 DNA methylation levels

−0.177

0.038

−0.367*

-

-

-

Adjusted for sex

      

LEP -CpG17 DNA methylation levels

−0.152

−0.021

−0.282

-

-

-

Adjusted for sex and LDL-C levels

      
  1. Pearson correlations are statistically significant: p ≤ 0.10; *p ≤ 0.05;**p ≤ 0.01.