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Table 3 Pearson correlation coefficients between low-density lipoprotein cholesterol (LDL-C) levels, LEP mRNA and LEP gene CpG17 DNA methylation levels in subcutaneous adipose tissue (SAT) according to the rs2167270 genotype

From: Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women

  LEP mRNA levels LEP -CpG17 DNA methylation levels
  ALL GG GA/AA ALL GG GA/AA
  n = 73 n = 30 n = 43 n = 73 n = 30 n = 43
LDL-C levels −0.097 0.142 −0.317* 0.370** 0.400* 0.384**
Adjusted for sex and waist girth
LDL-C levels −0.035 0.138 −0.205 - - -
Adjusted for sex, waist girth and LEP-CpG17 DNA methylation levels
LDL-C levels - - - 0.360** 0.399* 0.303
Adjusted for sex, waist girth and LEP mRNA levels
LEP -CpG17 DNA methylation levels −0.177 0.038 −0.367* - - -
Adjusted for sex       
LEP -CpG17 DNA methylation levels −0.152 −0.021 −0.282 - - -
Adjusted for sex and LDL-C levels       
  1. Pearson correlations are statistically significant: p ≤ 0.10; *p ≤ 0.05;**p ≤ 0.01.