Skip to main content

Advertisement

Table 2 Pearson correlation coefficients between fasting LDL-C levels and both LEP and ADIPOQ DNA methylation and mRNA levels in subcutaneous (SAT) and visceral adipose tissues (VAT)

From: Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women

  LDL-C levels (mmol/L) Adjusted for age and sex LDL-C levels (mmol/L) Adjusted for age, sex and WG
  r P r p
BLOOD     
LEP-CpG7 0.133 0.27 0.122 0.31
LEP-CpG11 0.222 0.06 0.206 0.09
LEP-CpG17 0.239 0.04 0.234 0.05
LEP-Mean 0.178 0.138 0.162 0.18
ADIPOQ-CpGE3 a 0.161 0.17 0.149 0.22
SAT     
LEP-CpG7 0.090 0.46 0.108 0.37
LEP-CpG11 0.215 0.07 0.231 0.06
LEP-CpG17 0.380 0.001 0.391 0.001
LEP-Mean 0.190 0.11 0.218 0.07
LEP mRNA levels −0.113 0.35 −0.098 0.42
ADIPOQ-CpGE1 0.176 0.14 0.236 0.05
ADIPOQ-CpGE3 0.242 0.04 0.292 0.01
ADIPOQ-Mean 0.206 0.08 0.268 0.03
ADIPOQ mRNA levels 0.024 0.85 0.009 0.94
VAT     
LEP-CpG7 0.130 0.28 0.131 0.28
LEP-CpG11 0.158 0.19 0.169 0.16
LEP-CpG17 0.114 0.34 0.127 0.30
LEP-Mean 0.256 0.03 0.273 0.02
LEP mRNA levels 0.160 0.18 0.034 0.78
ADIPOQ-CpGE1 0.270 0.02 0.267 0.03
ADIPOQ-CpGE3 0.188 0.12 0.181 0.14
ADIPOQ-Mean 0.250 0.04 0.245 0.04
ADIPOQ mRNA levels −0.111 0.37 −0.121 0.33
  1. WG,waist girth.
  2. aResults obtained after rank transformation of DNA methylation levels.
  3. Values in bold type are statistically significant: p ≤ 0.05.