Association of 42 SNPs with genetic risk for cervical cancer: an extensive meta-analysis

BMC Medical Genetics

Table 4 Meta-analysis results of special phenotypes

Gene symbol	Comparison	No.	Q	Q-P	I ²	Model	95% CI	P
GSTM1	postive/null	16	60.49	<0.00001	0.75	Random	0.70[0.53,0.92]	0.01
GSTT1	postive/null	15	69.88	<0.00001	0.8	Random	0.69[0.60,0.97]	0.03
G4C14-to-A4T14 P73	GG/GA + AA	2	0.61	0.44	0	Fixed	0.74[0.55,1.00]	0.05
P53 codon 72	C/G	44	268	<0.00001	0.84	Random	1.14[0.99,1.34]	0.07
P53 codon 72	CC/CG + GG	44	242.19	<0.00001	0.83	Random	1.18[0.96,1.42]	0.11
XRCC3 Codon 241	CC/CT + TT	5	6.35	0.17	0.37	Fixed	0.82[0.63,1.06]	0.14
G4C14-to-A4T14 P73	G/A	2	0.1	0.76	0	Fixed	0.83[0.65,1.07]	0.16
GSTP1	AA/AG + GG	2	0.97	0.61	0	Fixed	0.88[0.69,1.11]	0.28
XRCC1 Codon 194	CC/CT + TT	9	17.78	0.02	0.55	Fixed	0.92[0.79,1.08]	0.32
XRCC1 Codon399	GG/GA + AA	12	61.12	<0.0001	0.82	Random	1.18[0.84,1.64]	0.33
XRCC1 Codon399	G/A	12	203.12	<0.00001	0.95	Random	1.23[0.80,1.91]	0.34
XRCC1 Codon194	CC + CT/TT	9	21.11	0.007	0.62	Random	0.78[0.41,1.46]	0.44
GSTP1	A/G	2	0.03	0.86	0	Fixed	0.93[0.76,1.14]	0.48
G4C14-to-A4T14 P73	GG + GA/AA	2	0.89	0.34	0	Fixed	1.23[0.60,2.52]	0.56
P53 codon 72	CC + CG/GG	44	99.69	<0.0001	0.59	Random	1.06[0.90,1.23]	0.57
XRCC1 Codon399	GG + GA/AA	11	171.77	<0.0001	0.94	Random	1.22[0.49,3.01]	0.67
GSTP1	AA + AG/GG	2	0.1	0.76	0	Fixed	0.93[0.51,1.69]	0.80
XRCC3 Codon241	CC + CT/TT	5	13.95	0.003	0.78	Random	0.88[0.27,2.85]	0.83
XRCC1 Codon194	C/T	9	25.69	<0.00001	0.69	Random	0.99[0.73,1.33]	0.93

No, number of studies; OR, combined odds ratio; CI, confidence interval; P, P value.

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