Table 3 Meta-analysis results under the recessive genetic model
From: Association of 42 SNPs with genetic risk for cervical cancer: an extensive meta-analysis
SNP | Comparison | Gene symbol | No. | Q | Q-P | I 2 | Model | 95% CI | P |
|---|---|---|---|---|---|---|---|---|---|
rs1048943 | GG/GA + AA | CYP1A1A4889G | 8 | 14.4 | 0.04 | 0.51 | Fixed | 0.48[0.40,0.59] | <0.00001 |
rs16944 | CC/CT + TT | IL-1β | 4 | 3.37 | 0.34 | 0.11 | Fixed | 0.58[0.45,0.74] | <0.00001 |
rs4646903 | TT/TC + CC | CYPA1T6235C | 8 | 12.74 | 0.08 | 0.45 | Fixed | 1.98[1.46,2.69] | <0.00001 |
rs3212227 | AA/AC + CC | IL-12B | 2 | 1.36 | 0.24 | 0.26 | Fixed | 0.68[0.56,0.84] | 0.0002 |
rs187084 | TT/TC + CC | TLR9 T1486C | 3 | 0.93 | 0.63 | 0 | Fixed | 0.76[0.64,0.90] | 0.001 |
rs352140 | GG/GA + AA | TLR9 G2848A | 3 | 0.93 | 0.63 | 0 | Fixed | 0.76[0.64,0.90] | 0.001 |
rs2279744 | TT/TG + GG | MDM2 | 2 | 15.8 | <0.00001 | 0.94 | Random | 0.59[0.42,0.84] | 0.003 |
rs568408 | GG/GA + AA | IL12A | 2 | 0.3 | 0.59 | 0 | Fixed | 0.74[0.61,0.91] | 0.004 |
rs1800872 | CC/AC + AA | IL-10 C592A | 5 | 6.67 | 0.15 | 0.4 | Fixed | 0.84[0.72,0.99] | 0.04 |
rs1800896 | GG/GA + AA | IL-10 G1082A | 8 | 22.99 | 0.0008 | 0.74 | Random | 0.66[0.44,0.99] | 0.04 |
rs1800795 | GG/GC + CC | IL-6 | 2 | 1.35 | 0.24 | 0.26 | Fixed | 0.70[0.49,1.00] | 0.05 |
rs1800629 | GG/GA + AA | TNF-α-308 | 15 | 38.57 | 0.0004 | 0.64 | Random | 0.85[0.71,1.02] | 0.08 |
rs361525 | GG/GA + AA | TNF-α-238 | 8 | 372 | <0.0001 | 0.98 | Random | 2.94[0.82,10.5] | 0.10 |
rs3021097 | CC/CT + TT | IL-10 C819T | 2 | 1.2 | 0.27 | 0.17 | Fixed | 0.74[0.50,1.10] | 0.14 |
rs11134527 | AA/AG + GG | pri-miR-218 | 2 | 1.41 | 0.23 | 0.29 | Fixed | 1.09[0.96,1.23] | 0.18 |
rs3116496 | CC/CT + TT | CD28 | 3 | 0.18 | 0.92 | 0 | Fixed | 1.33[0.83,2.12] | 0.24 |
rs1801275 | AA/AG + GG | IL-4R | 2 | 0.26 | 0.61 | 0 | Fixed | 1.13[0.89,1.42] | 0.31 |
rs763110 | TT/TC + CC | FASL T844C | 2 | 3.79 | 0.05 | 0.74 | Fixed | 0.83[0.58,1.19] | 0.31 |
rs1805087 | AA/AG + GG | MTR A2756G | 3 | 34.25 | <0.00001 | 0.94 | Random | 1.79[0.57,5.62] | 0.32 |
rs1801131 | AA/AC + CC | MTHFRA1298C | 2 | 0.25 | 0.62 | 0 | Fixed | 0.87[0.66,1.15] | 0.33 |
rs1052134 | Ser326Cys | OGG1 | 2 | 0.58 | 0.45 | 0 | Fixed | 1.20[0.78,1.84] | 0.40 |
rs5275 | CC/CT + TT | COX-2 | 2 | 6.18 | 0.01 | 0.84 | Fixed | 0.73[0.36,1.50] | 0.40 |
rs5742909 | TT/TC + CC | CTLA-318 | 5 | 2.33 | 0.68 | 0 | Fixed | 1.42[0.63,3.20] | 0.40 |
rs11549465 | CC/CT + TT | HIF1A C1772T | 2 | 8 | 0.005 | 0.87 | Random | 0.57[0.13,2.45] | 0.45 |
rs1799864 | GG/GA + AA | CCR2 | 3 | 6.93 | 0.03 | 0.71 | Fixed | 0.87[0.48,1.58] | 0.65 |
rs1800682 | GG/GA + AA | Fas | 9 | 38.81 | <0.0001 | 0.79 | Random | 0.92[0.67,1.26] | 0.69 |
rs603965 | GG/GA + AA | CCND1 | 7 | 17.2 | 0.0009 | 0.65 | Random | 0.94[0.69,1.29] | 0.70 |
rs3025039 | CC/CT + TT | VEGF C936T | 2 | 0 | 1 | 0 | Fixed | 1.08[0.72,1.62] | 0.71 |
rs833061 | TT/TC + CC | VEGF T460C | 2 | 1.94 | 0.16 | 0.49 | Fixed | 1.07[0.75,1.51] | 0.71 |
rsl801270 | CC/AC + AA | p21codon 31 | 8 | 46.83 | <0.00001 | 0.85 | Random | 1.07[0.71,1.62] | 0.74 |
rs1801133 | TT/TC + CC | MTHFR C677T | 9 | 10.53 | 0.23 | 0.24 | Fixed | 1.03[0.85,1.25] | 0.76 |
rs62559044 | AA/AT + TT | IFN-r A874T | 4 | 37.06 | <0.00001 | 0.92 | Random | 0.92[0.41,2.09] | 0.85 |
rs4404252 | TT/TC + CC | ICOS T/C | 2 | 0.13 | 0.72 | 0 | Fixed | 1.01[0.84,1.22] | 0.91 |