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Table 1 Meta-analysis results under the allele model

From: Association of 42 SNPs with genetic risk for cervical cancer: an extensive meta-analysis

SNP

Comparison

Gene symbol

No.

Q

Q-P

I 2

Model

95% CI

P

rs1048943

G/A

CYP1A1 A4889G

8

12.72

0.08

0.45

Fixed

1.75[1.49,2.05]

<0.00001

rs3212227

A/C

IL-12B

2

3.97

0.05

0.75

Fixed

0.75[0.64,0.87]

0.0001

rs2279744

T/G

MDM2

2

16.6

<0.00001

0.94

Random

0.64[0.50,0.82]

0.0004

rs16944

C/T

IL-1β

4

10.06

0.02

0.7

Fixed

0.79[0.69,0.90]

0.0006

rs187084

T/C

TLR9 T1486C

3

2.18

0.34

0.08

Fixed

0.84[0.75,0.95]

0.005

rs4646903

C/T

CYPA1 T6235C

8

33.46

<0.00001

0.79

Random

1.59[1.39,1.81]

0.005

rs568408

G/A

IL-12A

2

0.05

0.83

0

Fixed

0.78[0.66,0.93]

0.006

rs1800872

C/A

IL-10 C592A

5

4.69

0.32

0.15

Fixed

0.85[0.76.0.96]

0.007

rs1800795

G/C

IL-6

2

0

0.94

0

Fixed

0.69[0.51,0.92]

0.01

rs11134527

A/G

pri-miR-218

2

0.72

0.39

0

Fixed

1.11[1.02,1.21]

0.02

rs1800629

G/A

TNF-α-308

15

56.89

<0.00001

0.77

Random

0.82[0.68,0.98]

0.03

rs1801275

A/G

IL-4R

2

0.24

0.63

0

Fixed

1.18[0.98,1.42]

0.09

rs1052134

Ser326Cys

OGG1

2

0

0.96

0

Fixed

1.26[0.94,1.68]

0.12

rs603965

G/A

CCND1

6

6.6

0.25

0.24

Fixed

0.92[0.82,1.03]

0.14

rs361525

G/A

TNF-α-238

8

805.51

<0.00001

0.99

Random

2.90[0.65,12.9]

0.16

rs5742909

T/C

CTLA-318

5

18.55

0.001

0.78

Random

1.39[0.87,2.21]

0.17

rs62559044

A/T

IFN-r A874T

4

26.88

<0.00001

0.89

Random

1.10[0.94,1.29]

0.21

rs1801133

T/C

MTHFR C677T

8

35.6

<0.00001

0.8

Random

0.87[0.67,1.12]

0.27

rs352140

G/A

TLR9 G2848A

3

0.26

0.61

0

Fixed

1.09[0.92,1.29]

0.30

rs833061

T/C

VEGF T460C

2

0.39

0.53

0

Fixed

1.14[0.86,1.50]

0.35

rs11549465

C/T

HIF1A C1772T

2

11.76

0.0006

0.91

Random

0.56[0.13,2.32]

0.42

rs1805087

A/G

MTR A2756G

2

32.02

<0.00001

0.97

Random

1.95[0.34,11.18]

0.45

rs763110

T/C

FASL T844C

2

13.02

0.0003

0.92

Random

0.81[0.47,1.40]

0.45

rs1800896

G/A

IL-10 G1082A

8

5.77

0.441

0

Fixed

1.00[0.91,1.09]

0.45

rs3021097

C/T

IL-10 C819T

2

3.09

0.08

0.68

Fixed

0.92[0.72,1.16]

0.47

rs1800682

G/A

Fas

9

22.37

0.004

0.64

Random

1.06[0.90,1.24]

0.48

rs1801131

A/C

MTHFR A1298C

2

2.84

0.09

0.65

Fixed

1.08[0.86,1.36]

0.50

rs3116496

C/T

CD28

3

13.94

0.0009

0.86

Random

1.14[0.76,1.71]

0.52

rs1799864

A/G

CCR2

3

84.35

<0.00001

0.98

Random

1.30[0.46,3.69]

0.62

rs5275

C/T

COX-2

2

1.1

0.29

0.09

Fixed

0.95[0.75,1.22]

0.70

rs861539

C/T

XRCC3Codon241

5

16

0.003

0.75

Random

0.92[0.58,1.44]

0.70

rs3025039

C/T

VEGF C936T

2

1.19

0.28

0.16

Fixed

1.06[0.77,1.45]

0.72

rs2031920

c1/c2

CYP2E1

2

0.2

0.66

0

Fixed

1.03[0.71,1.50]

0.87

rsl801270

C/A

p21 codon 31

7

55.68

<0.00001

0.89

Random

0.97[0.69,1.38]

0.87

rs4404252

T/C

ICOS

2

0.08

0.77

0

Fixed

1.01[0.86,1.18]

0.93

  1. No, number of studies; OR, combined odds ratio; CI, confidence interval; P, P value.